Improving anal cancer screening for people with HIV using genetic testing
Optimization of anal cancer screening for people with HIV using genomic methods
This study is looking to improve how we check for anal cancer in people living with HIV by testing a new, gentler method that uses a special brush to collect samples, and we want to see if it works better than the usual tests.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10785779 on NIH RePORTER |
What this research studies
This research focuses on enhancing the screening process for anal cancer in individuals living with HIV by utilizing genomic methods. The study aims to compare a new genomic test, which uses a cytobrush for sample collection, against standard screening techniques that often yield inaccurate results. By enrolling a cohort of 250 participants, the research will gather data to identify genetic markers associated with precancerous anal lesions, potentially leading to more accurate and less invasive screening methods. The goal is to improve early detection and treatment of anal cancer, thereby reducing morbidity and mortality in this high-risk population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are at high risk for anal cancer.
Not a fit: Patients who do not have HIV or those who are not at risk for anal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and less invasive screening methods for anal cancer, ultimately improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using genomic methods for cancer screening, indicating potential success for this novel approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Silvera, Richard — Icahn School of Medicine at Mount Sinai
- Study coordinator: Silvera, Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.