Screen-and-treat program to prevent anal cancer in people with HIV
Integrated Model for the Prevention of Anal Cancer using screen and Treat for HSIL (IMPACT)
This project offers regular anal screening and treatment to men who have sex with men living with HIV to lower their risk of anal cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11392743 on NIH RePORTER |
What this research studies
You would be offered screening for high-grade anal lesions (HSIL) and same-site treatment as part of routine HIV care at an MSM-friendly clinic. The team will train local clinicians, use existing clinic systems, and strengthen follow-up so more people who need treatment actually get it. This adapts a proven U.S. prevention approach to the TRUST clinic in Nigeria after finding prior under-detection and treatment gaps. Visits may include exams, HPV testing, biopsies, treatment of HSIL, and ongoing monitoring.
Who could benefit from this research
Good fit: Ideal participants are men who have sex with men living with HIV who receive care at the TRUST clinic or similar HIV clinics in Nigeria and can attend screening and follow-up visits.
Not a fit: People without HIV, those who are not MSM, or anyone unable to attend the local clinic visits are unlikely to benefit from this program.
Why it matters
Potential benefit: If successful, this could lower anal cancer rates by finding and treating precancerous anal lesions earlier in people with HIV.
How similar studies have performed: A randomized trial at 21 U.S. sites showed that treating HSIL prevents anal cancer, so this work adapts a proven prevention method to a Nigerian clinic setting.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Nowak, Rebecca G. — University of Maryland Baltimore
- Study coordinator: Nowak, Rebecca G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.