Preventing anal cancer in people living with HIV
Prevention of anal cancer in People Living with HIV (PLWH)
This study is looking for better ways to prevent anal cancer in people with HIV by testing a new treatment for precancerous conditions, hoping to find options that work well and have fewer side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wm S. Middleton Memorial Veterans Hosp NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10948112 on NIH RePORTER |
What this research studies
This research focuses on preventing anal cancer, which is increasingly common among individuals living with HIV, particularly due to the effects of human papillomaviruses (HPVs). The study aims to improve treatment for precancerous anal conditions known as anal dysplasia, which currently have high recurrence rates and side effects. By utilizing a new mouse model and exploring the effects of HIV protease inhibitors, the research seeks to develop a topical treatment that targets the underlying mechanisms of cancer development. Patients may benefit from innovative therapies that could reduce the risk of progressing to anal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults living with HIV who are at risk for anal dysplasia or anal cancer.
Not a fit: Patients who do not have HIV or those without precancerous anal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments that significantly lower the incidence of anal cancer in people living with HIV.
How similar studies have performed: Previous research has shown promise in repurposing HIV protease inhibitors for cancer prevention, indicating a potential for success in this novel approach.
Where this research is happening
Madison, United States
- Wm S. Middleton Memorial Veterans Hosp — Madison, United States (Active)
Researchers
- Principal investigator: Carchman, Evie — Wm S. Middleton Memorial Veterans Hosp
- Study coordinator: Carchman, Evie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.