Detecting pancreatic dysfunction in adults with type 2 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional, single-visit study in outpatient clinics in the Aktobe region of Kazakhstan enrolls adults with type 2 diabetes of up to five years' duration and conducts a standardized evaluation of pancreatic endocrine and exocrine function. Participants provide blood for glucose, insulin, adiponectin, TGF-beta1 and other markers, a stool sample for fecal elastase-1, complete a digestive-symptom questionnaire, and undergo pancreatic ultrasound. Recruitment is consecutive across multiple regional outpatient sites coordinated by West Kazakhstan Marat Ospanov Medical University. No treatments are given as part of the visit; collected data will be analyzed to see how blood markers and imaging relate to pancreatic function and the presence of pancreatogenic diabetes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • adult patients of Kazakh nationality aged 18 to 74 years
* diagnosis of T2DM established according to ADA criteria and documented in medical records
* disease duration ≤5 years
* absence of ketoacidosis episodes within the last 6 months

Exclusion Criteria:

* positive anti-glutamic acid decarboxylase antibodies (anti-GAD65);
* acute or chronic infections affecting metabolic status within the previous 4 weeks;
* any history of malignant neoplasms;
* pregnancy or lactation;
* previously diagnosed type 1 diabetes mellitus or other specific types of diabetes;
* severe decompensated chronic diseases;
* conditions associated with systemic fibrosis (e.g., liver cirrhosis or autoimmune diseases);
* refusal to participate.

Where it's running

• Outpatient clinics of Aktobe region, West Kazakhstan Marat Ospanov Medical University
  Aktobe, Aktobe, Kazakhstan Recruiting

Study contacts

• Study coordinator: Mengtay S Makashova
• Email: ersultanbeknur@gmail.com
• Phone: +77058440060

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.