Local steroid injection in carpal tunnel syndrome with diabetes vs without diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study comparing recovery after a corticosteroid plus lidocaine injection between two groups: CTS patients with type 2 diabetes and CTS patients without diabetes. Participants have mild-to-moderate CTS confirmed by electrophysiology and receive a standard injection. Data are collected before treatment and at 4 and 12 weeks, including symptoms, function, and nerve measurements, to see if diabetes affects post-injection recovery. The study uses patient-reported outcomes and objective nerve studies to characterize differences in recovery trajectories between groups.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Carpal Tunnel Syndrome with Type 2 Diabetes Mellitus Group (Group 1):

  * Age between 18 and 75 years
  * Presence of clinical symptoms compatible with carpal tunnel syndrome (e.g., pain, paresthesia, numbness) for at least 3 months
  * Patients diagnosed with mild-to-moderate carpal tunnel syndrome based on electrophysiological findings
  * Diagnosis of type 2 diabetes mellitus
  * Regulated blood glucose levels, defined as hemoglobin A1c (HbA1c) \< 7%
* Idiopathic Carpal Tunnel Syndrome Group (Group 2):

  * Age between 18 and 75 years
  * Presence of clinical symptoms consistent with carpal tunnel syndrome (e.g., pain, paresthesia, numbness) for at least 3 months
  * Patients diagnosed with mild-to-moderate carpal tunnel syndrome based on electrophysiological findings
  * No diagnosis of diabetes mellitus

Exclusion Criteria

* Severe carpal tunnel syndrome based on electrophysiological findings
* Presence of polyneuropathy, cervical radiculopathy, brachial plexopathy, or thoracic outlet syndrome
* Uncontrolled blood glucose levels in the diabetic group (hemoglobin A1c ≥ 7%)
* Presence of another systemic disease, other than diabetes mellitus, that may cause carpal tunnel syndrome
* Presence of a rheumatological disease
* History of wrist surgery
* Less than 6 months since a local corticosteroid injection for carpal tunnel syndrome
* Less than 3 months since completion of a physical therapy program for carpal tunnel syndrome
* Infection at the intended injection site
* Presence of malignancy
* Pregnancy

Where it's running

• Istanbul Haydarpasa Numune Training and Research Hospital
  Istanbul, Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Talha Çeli̇k
• Email: talhacelikdr@gmail.com
• Phone: +905062398047

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.