Condition

Obesity and Overweight clinical trials and research

• 40Clinical trials
• 14Countries

Newest Obesity and Overweight clinical trials

All recruiting trials (40)

• IBI3046 in Overweight or Obesity

  This study tests how safe and tolerable IBI3046 is in adults with overweight or obesity in China.

  Recruiting Phase 1 Innovent Biologics (Suzhou) Co. Ltd. · Beijing, Beijing Municipality · NCT07809945

• Sleep behavioral program for adolescents with overweight or obesity

  This trial will test whether adding a sleep-focused behavioral program to usual weight treatment helps teens (13–17) with overweight or obesity who have poor sleep improve body composition and health markers.

  Recruiting University of Beira Interior · Covilha and 1 other locations · NCT07255274

• Robotic versus laparoscopic conversion to RYGB for revision bariatric surgery

  We will see if robotic surgery or laparoscopy leads to fewer postoperative complications for people having revision bariatric surgery converted to RYGB.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Lyon and 1 other locations · NCT07180316

• Bone health, vitamin D, weight, and fractures in children

  See if blood markers (alkaline phosphatase, calcium, PTH, vitamin D), body weight, and calcium intake are linked to fractures in children aged 3–15 after low-energy trauma.

  Recruiting at 2 sites Paracelsus Medical University · Brixen, Bolzano and 1 other locations · NCT07143552

• Efsubaglutide alfa for adults with overweight or obesity (SPARKLE)

  This trial will test whether efsubaglutide alfa injections given weekly or every few weeks help adults with overweight or obesity lose weight safely.

  Recruiting at 5 sites Phase 2 Shanghai Yinnuo Pharmaceutical Technology Co., Ltd. · Brookvale and 4 other locations · NCT07114419

• Cardiovascular health in children and young adults with chronic conditions

  This project will see if children and young adults (ages 6-25) with chronic health conditions show early signs of aging in large and small blood vessels using noninvasive imaging and clinical tests.

  Recruiting Semmelweis University · Budapest and 2 other locations · NCT07086989

• FRESH-EATS: a family healthy eating program.

  This program tries to see if FRESH-EATS helps children ages 8-12 and their parents/caregivers in low-income neighborhoods eat healthier.

  Recruiting University of South Florida · Tampa, Florida · NCT07053644

• Improving team-based biopsychosocial training so clinics can deliver recommended obesity care

  This project will test two training methods to help clinic teams (primary care clinicians, behavioral health staff, dietitians, and community health workers) deliver USPSTF-recommended obesity care to patients at Federally Qualified Health Centers.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07049861

• Heart, kidney, and metabolic health in Shanghai community residents

  This follow-up will track people from the STONE cohort to see if changes in metabolic risk factors over time relate to heart and kidney outcomes.

  Recruiting Shanghai Changzheng Hospital · Shanghai, Shanghai Municipality · NCT07043166

• Daily broccoli microgreens for breast cancer survivors with obesity

  This two-week test will see if eating one cup of fresh broccoli microgreens each day is doable and changes metabolism and gut health in obese breast cancer survivors.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT07032545

• Behavioral weight loss intervention for college students

  This study is testing a new weight loss program for college students aged 18-25 who are overweight to see if small changes in their eating and activity habits can help them lose weight.

  Recruiting The Miriam Hospital · Providence, Rhode Island · NCT06994923

• Tirzepatide to help reduce drinking in adults with alcohol use disorder who are overweight

  This trial will test whether weekly tirzepatide injections help adults with alcohol use disorder and overweight or obesity drink less and improve heart and metabolic health compared with placebo.

  Recruiting Phase 2 University of Southern California · Los Angeles, California · NCT06994338

• Reducing heart disease risk in 12–15-year-olds with severe obesity

  This will try semaglutide in 12–15-year-olds with class 2–3 obesity to see if it changes weight, heart-related risk markers, body composition, and fitness over about a year.

  Recruiting University of Kentucky · Lexington, Kentucky · NCT06967389

• Lowering blood pressure by adding stair climbing to brisk walking

  We will test whether adding short daily stair climbing to a brisk-walking program lowers systolic blood pressure in adults 35 and older who have high blood pressure, are overweight, and are not regularly active.

  Recruiting Karolinska Institutet · Stockholm and 3 other locations · NCT06952348

• Predicting Quality of Life After Bariatric Surgery from Pre-Surgery Profiles

  This study tests whether pre-surgical patient traits can predict how quality of life changes after bariatric surgery for adults in the GEROM73 program.

  Recruiting Centre Hospitalier Metropole Savoie · Chambéry, Savoie · NCT06951893

• Impact of Peanut Consumption on Health During Weight Loss in Older Adults

  This study is testing if eating peanuts every day can help older adults who are trying to lose weight improve their bone health and overall well-being compared to those who don’t eat peanuts.

  Recruiting Rutgers, The State University of New Jersey · New Brunswick, New Jersey · NCT06949280

• Using semaglutide to treat psoriasis in obese patients

  This study is testing if the weight loss drug semaglutide can help improve psoriasis symptoms in adults who are both obese and have psoriasis.

  Recruiting Phase 3 The University of Hong Kong · Hong Kong · NCT06937060

• Using wearable devices to improve health in high-risk stroke patients

  This study is testing if smart wearable devices can help high-risk stroke patients manage their health better by reminding them to take medication, monitor their heart rate, and encourage exercise.

  Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT06935513

• Improving energy balance in overweight individuals through exercise and cognitive training

  This study is testing if combining exercise with mental and social training can help overweight people, including kids, feel more satisfied with their food and improve their overall health.

  Recruiting at 2 sites Bambino Gesù Hospital and Research Institute · Rome, Italy and 1 other locations · NCT06931730

• Precision nutrition to prevent diabetes and other metabolic diseases

  This trial will try personalized diets based on each person's metabolic 'metabotype' to see if they improve blood sugar control and prevent type 2 diabetes in adults with overweight or obesity.

  Recruiting at 2 sites Maastricht University Medical Center · Maastricht and 1 other locations · NCT06923644

• Investigating factors influencing childhood obesity

  This study looks at why some kids become overweight by checking their eating habits, genetics, and brain development to find ways to help prevent or treat obesity early on.

  Recruiting Johns Hopkins University · Baltimore, Maryland and 3 other locations · NCT06861868

• Calorie-reduced Mediterranean diet plus activity program to lower chronic disease risk in 30–50-year-olds

  This program will try a 25% calorie-reduced Mediterranean diet combined with increased physical activity to help 30–50-year-olds with metabolic syndrome lose weight and improve cardiometabolic health.

  Recruiting IMDEA Food · Madrid, Madrid · NCT06857929

• Time-restricted eating for menopausal women and those on hormone therapy for breast cancer

  This trial will test whether eating only during an 8-hour window each day (16:8 time-restricted eating) helps overweight menopausal women and women taking aromatase inhibitors manage weight and symptoms.

  Recruiting University Hospital, Geneva · Geneva, Canton of Geneva · NCT06855784

• Investigating protein needs after gastric bypass surgery

  This study tests how much protein adult men need after having gastric bypass surgery to see if their needs are different from those of the general population.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT06853652

• Impact of ultra processed food on energy storage in the body

  This study is testing how eating mostly ultra processed foods affects energy storage in people with obesity.

  Recruiting Columbia University · New York, New York · NCT06853288

• Tirzepatide versus lisdexamfetamine and placebo for adults with obesity and binge-eating disorder

  This trial tests whether tirzepatide helps reduce binge-eating episodes and body weight in adults with obesity and moderate-or-greater binge-eating disorder, compared with lisdexamfetamine or placebo, with all participants receiving guided self-help CBT.

  Recruiting Phase 2 Johns Hopkins University · Baltimore, Maryland · NCT06847399

• Time-restricted eating plus a healthy diet for people with liver cancer

  This trial will try an 8–10 hour time-restricted eating plan together with targeted healthy food changes for overweight adults with early-to-intermediate liver cancer who are having liver-directed therapy.

  Recruiting University of California, San Diego · La Jolla, California · NCT06824974

• Exploring how probiotics affect energy metabolism after meals in older adults

  This study is testing if taking probiotics can help older adults who are moderately overweight improve their energy and metabolism after meals.

  Recruiting Phase 2 Lallemand Health Solutions · Pierre-Bénite, Auvergne-Rhône-Alpes · NCT06786052

• Gut fermentation and metabolism in teens and young adults with obesity

  This will test whether giving lactulose to teens and young adults with obesity and insulin resistance changes gut fermentation in ways that lower fat release from fat tissue and reduce appetite.

  Recruiting Yale University · New Haven, Connecticut · NCT06768827

• Effects of kombucha on overweight and obese individuals

  This study is testing whether drinking live or pasteurized kombucha can help people who are overweight or mildly obese improve their health over four weeks.

  Recruiting at 2 sites Associação Centro de Apoio Tecnológico Agro Alimentar · Castelo Branco, Castelo Branco District and 1 other locations · NCT06759324

• Investigating glucose utilization in obesity

  This study is testing how emotions and cold temperatures affect blood flow and insulin's role in helping people with obesity use glucose better.

  Recruiting Phase 4 Turku University Hospital · Turku · NCT06739473

• Gastric ablation therapy for weight management after stopping GLP-1 medications

  This study tests if a procedure called gastric ablation can help adults keep off weight they lost with GLP-1 medications after they stop taking them.

  Recruiting True You Weight Loss · Cary, North Carolina and 1 other locations · NCT06734312

• Family-centered weight loss program for Black adults

  This study is testing a weight loss program for Black adults that involves family support to see which family activities help them lose weight best over six months.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT06724406

• CHIME: Comparing approaches to support healthy pregnancy and postpartum weight

  This trial will try two different support programs versus usual care to see if they help pregnant people from early pregnancy through one year after birth keep a healthier weight.

  Recruiting at 3 sites Stanford University · Palo Alto, California and 3 other locations · NCT06724172

• Effects of Bariatric Surgery and Liraglutide on Weight Loss and Brain Function in Obesity

  This study tests how bariatric surgery and the medication liraglutide affect weight loss and brain function in people with obesity.

  Recruiting I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio · Milan, Milan · NCT06720246

• Exploring the effects of obesity medications combined with exercise on body composition

  This study is testing if combining obesity medications with different types of exercise can help people lose fat and gain muscle over six months.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06645470

• Comparing aerobic exercise with yoga for weight loss in overweight adults

  This study is testing if adding yoga to a weight loss program helps overweight adults lose more weight than just doing aerobic exercise alone.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06636773

• Mobile program to reduce pain and improve health in older adults with osteoarthritis

  This trial tests a mobile group-based program combining frequent movement and dietary changes to help older adults with obesity and knee or hip osteoarthritis lose weight, move more, and reduce pain.

  Recruiting Phase 2 Wake Forest University · Winston-Salem, North Carolina · NCT06623669

• Effects of eating watermelon on gut and heart health

  This study is testing if eating fresh watermelon every day for six weeks can improve gut and heart health in young adults who are overweight or obese.

  Recruiting Florida State University · Tallahassee, Florida · NCT06588218

• Weight loss app for adolescents

  This study is testing a new smartphone app to help teenagers with obesity cut down on overeating by getting their feedback during the development process.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT05530538

Related topics

Quick answers

How many Obesity and Overweight clinical trials are recruiting right now?

40, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (20 trials), Italy (3 trials), France (3 trials), China (3 trials), Portugal (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 3: 1, Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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