Targeting a specific pathway to prevent sudden cardiac death in heart failure patients
The KChIP2-JNK2 axis as a therapeutic target for sudden cardiac death
This study is looking at a specific pathway in the heart to see if it can help reduce the risk of sudden cardiac death in people with heart failure, and it hopes to find new treatments to manage dangerous heart rhythms that can happen with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11162447 on NIH RePORTER |
What this research studies
This research investigates the KChIP2-JNK2 signaling pathway as a potential therapeutic target to reduce the risk of sudden cardiac death (SCD) in patients with heart failure. The study aims to understand how this pathway contributes to arrhythmias and cardiac dysfunction, which are common in heart failure. By exploring the molecular mechanisms involved, the researchers hope to develop new treatments that can effectively manage or prevent these dangerous heart rhythms. Patients may be involved in trials assessing new therapies that target this pathway.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure who are at risk of sudden cardiac death.
Not a fit: Patients without heart failure or those who do not have a history of arrhythmias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of sudden cardiac death in heart failure patients.
How similar studies have performed: While this approach is innovative, similar research targeting molecular pathways in cardiac arrhythmias has shown promise in other contexts.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Deschenes, Isabelle — Ohio State University
- Study coordinator: Deschenes, Isabelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.