Targeting a specific pathway to prevent sudden cardiac death in heart failure patients
Official title: The KChIP2-JNK2 axis as a therapeutic target for sudden cardiac death
Funded at Ohio State University · NIH-11162447 · Data updated 2026-11-12
This study is looking at a specific pathway in the heart to see if it can help reduce the risk of sudden cardiac death in people with heart failure, and it hopes to find new treatments to manage dangerous heart rhythms that can happen with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 6, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $783,860 |
| NIH project number | 5R01HL174911-02 |
| Project ID | NIH-11162447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure who are at risk of sudden cardiac death.
✕Less likely to help
Patients without heart failure or those who do not have a history of arrhythmias may not benefit from this research.
What this research studies
This research investigates the KChIP2-JNK2 signaling pathway as a potential therapeutic target to reduce the risk of sudden cardiac death (SCD) in patients with heart failure. The study aims to understand how this pathway contributes to arrhythmias and cardiac dysfunction, which are common in heart failure. By exploring the molecular mechanisms involved, the researchers hope to develop new treatments that can effectively manage or prevent these dangerous heart rhythms. Patients may be involved in trials assessing new therapies that target this pathway.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of sudden cardiac death in heart failure patients.
How similar studies have gone: While this approach is innovative, similar research targeting molecular pathways in cardiac arrhythmias has shown promise in other contexts.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Deschenes, Isabelle — Ohio State University
- Study coordinator: Deschenes, Isabelle
Related research
Other NIH-funded projects on the same topics.
-
Imaging-Enhanced Prediction of Sudden Cardiac Death Risk in Pediatric Heart Disease
Aims to create a better, non-invasive way to predict which children with hypertrophic cardiomyopathy (HCM) are at risk of sudden death so doctors can choose who truly needs an ICD.
-
Dynamic predictors of sudden cardiac death in people with coronary artery disease
Aims to improve how we predict who is at risk of sudden cardiac death by looking at changes in heart signals over time.
-
KChIP2-JNK2 axis therapy for preventing sudden cardiac death
A new approach targets how heart cells mishandle calcium to reduce dangerous heart rhythms in people at risk of sudden death.
-
Finding why sudden cardiac death happens in dilated cardiomyopathy and how to stop it
Looks at whether genetics and heart scarring can predict and help prevent deadly heart rhythms in people with dilated cardiomyopathy.
-
Clonal blood-cell mutations and sudden cardiac death risk
This project looks for a connection between clonal blood-cell mutations (CHIP) and sudden cardiac death in adults.
-
Understanding the causes of sudden cardiac death in patients with dilated cardiomyopathy.
This study is looking at how certain genetic factors and heart changes can help doctors find out which patients with dilated cardiomyopathy are at risk for serious heart problems, so they can create better treatments and prevention plans for them.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.