Genetic assessment of young athletes who experience sudden cardiac arrest during sports

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This study looks at young athletes aged 12 to 35 who have had sudden cardiac arrest during sports to see if genetic factors played a role and to help prevent similar events in others.

Quick facts

• Study type: Observational
• Enrollment: 80 (estimated)
• Ages: 12 Years to 35 Years
• Sex: All
• Sponsor: Rennes University Hospital (other)
• Locations: 26 sites (Paris, France and 25 other locations)
• Trial ID: NCT06642168 on ClinicalTrials.gov

What this trial studies

This observational registry focuses on young individuals aged 12 to 35 who suffer from sudden cardiac arrest (SCA) or sudden cardiac death (SCD) related to sports activities. The study aims to identify the underlying causes of these events through comprehensive etiological assessments, including autopsies, whole exome genetic analysis, and toxicological testing. By understanding the genetic factors involved, the study seeks to provide insights that could help prevent similar incidents in family members of victims. The findings will contribute to a better understanding of the risks associated with sports participation in young athletes.

Who should consider this trial

Good fit: Ideal candidates for this study are young athletes aged 12 to 35 who have experienced a sudden cardiac arrest during or shortly after sports activities without any known cardiovascular pathology.

Not a fit: Patients who have pre-existing cardiovascular conditions or are older than 35 years may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved prevention strategies for sudden cardiac events in young athletes and their families.

How similar studies have performed: While studies on sudden cardiac arrest in athletes exist, this specific approach focusing on genetic assessment in young victims is relatively novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

* Victims of SCA:

  * Aged between 12 and 35 years
  * No known cardiovascular pathology
  * Experienced a sudden and non-traumatic SCA during or within one hour of participating in sports activities (leisure, training, or competition)
  * For resuscitated victims (SCA group): A person or legal representative who does not oppose participation in the research after being informed about the study (including individuals, organs, or authorities responsible for assisting or representing them if they are unable to express their wishes).
  * For non-resuscitated victims (SCD group): A person who has not formally objected to the reuse of their medical data during their lifetime.
* First-Degree Relatives:

  * A person or legal representative who does not oppose participation in the research after being informed about the study (including individuals, bodies, or authorities responsible for assisting or representing them if they are unable to express their wishes).

Non-Inclusion Criteria:

* For resuscitated SCA cases, individuals weighing less than 20 kg
* Victims or legal representatives who are subject to legal protection or deprived of their liberty

Where this trial is running

Paris, France and 25 other locations

• APHP Hôpital Bichat — Paris, France, France (NOT_YET_RECRUITING)
• APHP Hôpital Européen Georges Pompidou — Paris, France, France (NOT_YET_RECRUITING)
• CHU Rennes — Rennes, France, France (RECRUITING)
• CHRU Besançon — Besançon, France (NOT_YET_RECRUITING)
• CHU Bordeaux — Bordeaux, France (NOT_YET_RECRUITING)
• CHU Brest — Brest, France (NOT_YET_RECRUITING)
• CHU Caen — Caen, France (NOT_YET_RECRUITING)
• CHU Clermont-Ferrand — Clermont-Ferrand, France (NOT_YET_RECRUITING)
• APHP Hôpital Henri-Mondor — Créteil, France (NOT_YET_RECRUITING)
• CHU Dijon Bourgogne — Dijon, France (NOT_YET_RECRUITING)
• CHU de Grenoble Alpes — Grenoble, France (NOT_YET_RECRUITING)
• CHRU Lille — Lille, France (NOT_YET_RECRUITING)
• Hospices Civils de Lyon — Lyon, France (NOT_YET_RECRUITING)
• APHM Hôpitaux universitaires de Marseille — Marseille, France (NOT_YET_RECRUITING)
• CHRU Montpellier — Montpellier, France (NOT_YET_RECRUITING)
• CHRU Nancy — Nancy, France (NOT_YET_RECRUITING)
• CHU Nantes — Nantes, France (NOT_YET_RECRUITING)
• CHU de Nice — Nice, France (RECRUITING)
• APHP Hôpital Pitié-Salpêtrière — Paris, France (NOT_YET_RECRUITING)
• CHU Poitiers — Poitiers, France (NOT_YET_RECRUITING)
• CHU Reims — Reims, France (NOT_YET_RECRUITING)
• CHU Rouen — Rouen, France (NOT_YET_RECRUITING)
• CHU Saint-Etienne — Saint-Etienne, France (NOT_YET_RECRUITING)
• CHRU Strasbourg — Strasbourg, France (NOT_YET_RECRUITING)
• CHU Toulouse — Toulouse, France (NOT_YET_RECRUITING)
• CHRU Tours — Tours, France (RECRUITING)

Study contacts

• Principal investigator: Frédéric SCHNELL — Study Principal Investigator
• Study coordinator: Frédéric SCHNELL

Conditions: Sudden Cardiac Arrest, Sudden Cardiac Death, Sport related sudden cardiac arrest, Sport related sudden cardiac death, Young athlete, Etiological Diagnosis, Autopsy, Genetic