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Registry for hereditary cardiovascular diseases in Brazil

National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry

Observational Hospital do Coracao · NCT06546137

This study is trying to create a registry of Brazilian patients with hereditary heart diseases to see how common certain genetic changes are in people with these conditions.

Quick facts

Study typeObservational
Enrollment1211 (estimated)
SexAll
SponsorHospital do Coracao Academic / other
Locations27 sites (Rio Branco, Acre and 26 other locations)
Trial IDNCT06546137 on ClinicalTrials.gov

What this trial studies

This observational study aims to create a registry of Brazilian patients diagnosed with hereditary cardiovascular diseases by collecting both clinical and genomic data. Participants will undergo whole genome sequencing to identify common genetic alterations associated with these conditions. The study will involve interviews during routine medical visits to gather necessary information and consent. The primary focus is to understand the frequency of genetic mutations in the Brazilian population affected by various types of cardiomyopathy and related disorders.

Who should consider this trial

Good fit: Ideal candidates include individuals with a clinical diagnosis of hereditary cardiovascular diseases who are willing to participate in genetic counseling.

Not a fit: Patients who do not have a hereditary cardiovascular disease or cannot provide informed consent will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance the understanding and management of hereditary cardiovascular diseases in Brazil, leading to improved patient care.

How similar studies have performed: Other studies focusing on genetic registries for hereditary diseases have shown promise, suggesting that this approach could yield valuable insights.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Clinical diagnosis of a hereditary cardiovascular disease according to current clinical guidelines
* Agree to receive genetic counseling
* Sign informed consent form
* Provide the information required in the case report form

Exclusion Criteria:

* Signature absent from informed consent form
* Inadequate buccal swab (sample may be collected twice)

Where this trial is running

Rio Branco, Acre and 26 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Cardiomyopathy, HypertrophicCardiomyopathy, DilatedCardiomyopathy RestrictiveArrhythmogenic Right Ventricular DysplasiaNon-Compaction CardiomyopathyFamilial HypercholesterolemiaMarfan SyndromeEhlers-Danlos Syndrome, Vascular Type
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.