Dynamic predictors of sudden cardiac death in people with coronary artery disease
Official title: Dynamic Predictors of Sudden Cardiac Death
Funded at Cedars-Sinai Medical Center · NIH-11366828 · Data updated 2026-11-12
Aims to improve how we predict who is at risk of sudden cardiac death by looking at changes in heart signals over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 4, 2026 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,696,670 |
| NIH project number | 1R01HL181473-01A1 |
| Project ID | NIH-11366828 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with coronary artery disease who have multiple timepoints of ECG data and echocardiograms available for analysis.
✕Less likely to help
Patients without access to repeated ECG or echo data may not benefit from this approach.
What this research studies
This project focuses on people with coronary artery disease and uses repeatedly collected heart data to create a dynamic risk score for sudden cardiac death. It builds on prior work showing that how risk markers change over time can predict events better than a single snapshot. By combining static factors from a resting ECG with how those signals evolve and with heart imaging from echocardiograms, the study seeks to improve early warning of high-risk patients. An exploratory aim will look for modifiable risk factors that could be targeted to prevent SCD.
Why it matters
Potential benefit: If successful, this approach could lead to better, earlier identification of patients at high risk of sudden cardiac death and inform preventive strategies.
How similar studies have gone: Earlier work suggests that dynamic risk markers can improve prediction beyond static measurements, supporting the potential here.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Chugh, Sumeet S. — Cedars-Sinai Medical Center
- Study coordinator: Chugh, Sumeet S.
Related research
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This study is looking at a specific pathway in the heart to see if it can help reduce the risk of sudden cardiac death in people with heart failure, and it hopes to find new treatments to manage dangerous heart rhythms that can happen with this condition.
-
Understanding the causes of sudden cardiac death in patients with dilated cardiomyopathy.
This study is looking at how certain genetic factors and heart changes can help doctors find out which patients with dilated cardiomyopathy are at risk for serious heart problems, so they can create better treatments and prevention plans for them.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.