Imaging-Enhanced Prediction of Sudden Cardiac Death Risk in Pediatric Heart Disease
Official title: iPRISM (Imaging-enhanced Prediction of RIsk for Sudden cardiac death in hcM)
Funded at Oregon Health & Science University · NIH-11393844 · Data updated 2026-11-12
Aims to create a better, non-invasive way to predict which children with hypertrophic cardiomyopathy (HCM) are at risk of sudden death so doctors can choose who truly needs an ICD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 15, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,062,732 |
| NIH project number | 5R01HL174606-02 |
| Project ID | NIH-11393844 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents with hypertrophic cardiomyopathy who have MRI scans and genetic testing data available.
✕Less likely to help
Patients without HCM or without MRI/genetic data may not benefit from this tool.
What this research studies
This project will study genetic test results and heart MRI scars in children and teenagers with HCM to understand which patterns indicate higher risk of sudden cardiac death. By combining MRI findings, genetic information, and other risk factors, researchers will build a new risk-prediction tool. The team will first develop the tool using existing data and then test its accuracy in a separate group to ensure it works beyond the initial cohort.
Why it matters
Potential benefit: If successful, the new tool could reduce unnecessary ICD surgeries in low-risk patients while ensuring high-risk children receive timely protection.
How similar studies have gone: Preliminary studies suggest MRI scars and genetic data are linked to risk, but a dedicated pediatric prediction tool is needed.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Balaji, Seshadri — Oregon Health & Science University
- Study coordinator: Balaji, Seshadri
Related research
Other NIH-funded projects on the same topics.
-
Dynamic predictors of sudden cardiac death in people with coronary artery disease
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-
KChIP2-JNK2 axis therapy for preventing sudden cardiac death
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-
Finding why sudden cardiac death happens in dilated cardiomyopathy and how to stop it
Looks at whether genetics and heart scarring can predict and help prevent deadly heart rhythms in people with dilated cardiomyopathy.
-
Clonal blood-cell mutations and sudden cardiac death risk
This project looks for a connection between clonal blood-cell mutations (CHIP) and sudden cardiac death in adults.
-
Targeting a specific pathway to prevent sudden cardiac death in heart failure patients
This study is looking at a specific pathway in the heart to see if it can help reduce the risk of sudden cardiac death in people with heart failure, and it hopes to find new treatments to manage dangerous heart rhythms that can happen with this condition.
-
Understanding the causes of sudden cardiac death in patients with dilated cardiomyopathy.
This study is looking at how certain genetic factors and heart changes can help doctors find out which patients with dilated cardiomyopathy are at risk for serious heart problems, so they can create better treatments and prevention plans for them.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.