Understanding the connection between stroke and heart issues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the mechanisms and prognosis of stroke-heart syndrome, which occurs frequently after acute strokes and is linked to higher mortality rates. By utilizing multimodal imaging and multi-omics blood analysis, the study aims to uncover the neuro-humoral mechanisms behind this syndrome and its effects on functional outcomes, cognitive abilities, and emotional health in stroke patients. The research seeks to identify novel blood biomarkers and brain network mechanisms, potentially leading to new treatment strategies and an early-warning system for major complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients admitted within 48 hours of onset, confirmed by CT/MRI as having a stroke (including acute ischemic stroke and hemorrhagic stroke).
2. Moderate-to-severe stroke with NIHSS ≥ 5.

Exclusion Criteria:

1. Previous focal brain injury (such as stroke, brain surgery, traumatic brain injury, etc.).
2. Brain dysfunction caused by other major neurological disorders than stroke (such as brain tumors, epilepsy, Parkinson's disease, etc.).
3. Transient ischemic attack (TIA) and subarachnoid hemorrhage (SAH).
4. History of cardiac diseases (such as coronary heart disease, heart failure, severe arrhythmias, congenital heart disease, cardiac surgery, valvular heart disease, or undiagnosed significant cardiac symptoms).
5. Concomitant systemic diseases such as renal failure (eGFR \< 30), autoimmune disorders, severe infections, etc.
6. History of dementia, depression, or other psychiatric disorders.
7. Poor compliance and inability to cooperate with follow-up.

Where it's running

• Department of Neurology, Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
  Wuhan, Hubei, China Recruiting

Study contacts

• Principal investigator: Zhou Zhu, MD, PhD — Tongji Hospital, Tongji Medical College, Huazhong University of Science and Tech
• Study coordinator: Chensheng Pan, M.D.
• Email: pancs29@gmail.com
• Phone: +8618202738845

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.