Understanding the connection between stroke and heart issues
Mechanisms And Prognosis of Stroke-Heart Syndrome
Tongji Hospital · NCT06954103
This study is trying to understand how strokes affect heart health and overall well-being in stroke patients to find new ways to help them recover better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 658 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Tongji Hospital (other) |
| Locations | 1 site (Wuhan, Hubei) |
| Trial ID | NCT06954103 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the mechanisms and prognosis of stroke-heart syndrome, which occurs frequently after acute strokes and is linked to higher mortality rates. By utilizing multimodal imaging and multi-omics blood analysis, the study aims to uncover the neuro-humoral mechanisms behind this syndrome and its effects on functional outcomes, cognitive abilities, and emotional health in stroke patients. The research seeks to identify novel blood biomarkers and brain network mechanisms, potentially leading to new treatment strategies and an early-warning system for major complications.
Who should consider this trial
Good fit: Ideal candidates include patients admitted within 48 hours of stroke onset, confirmed by imaging, with moderate-to-severe stroke severity.
Not a fit: Patients with a history of significant cardiac diseases or other major neurological disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention and treatment strategies for patients suffering from stroke-heart syndrome.
How similar studies have performed: While the specific mechanisms of stroke-heart syndrome are not well understood, similar studies exploring the relationship between stroke and cardiac complications have shown promise in identifying risk factors and potential interventions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients admitted within 48 hours of onset, confirmed by CT/MRI as having a stroke (including acute ischemic stroke and hemorrhagic stroke). 2. Moderate-to-severe stroke with NIHSS ≥ 5. Exclusion Criteria: 1. Previous focal brain injury (such as stroke, brain surgery, traumatic brain injury, etc.). 2. Brain dysfunction caused by other major neurological disorders than stroke (such as brain tumors, epilepsy, Parkinson's disease, etc.). 3. Transient ischemic attack (TIA) and subarachnoid hemorrhage (SAH). 4. History of cardiac diseases (such as coronary heart disease, heart failure, severe arrhythmias, congenital heart disease, cardiac surgery, valvular heart disease, or undiagnosed significant cardiac symptoms). 5. Concomitant systemic diseases such as renal failure (eGFR \< 30), autoimmune disorders, severe infections, etc. 6. History of dementia, depression, or other psychiatric disorders. 7. Poor compliance and inability to cooperate with follow-up.
Where this trial is running
Wuhan, Hubei
- Department of Neurology, Tongji hospital, Tongji medical college, Huazhong University of Science and Technology — Wuhan, Hubei, China (RECRUITING)
Study contacts
- Principal investigator: Zhou Zhu, MD, PhD — Tongji Hospital, Tongji Medical College, Huazhong University of Science and Tech
- Study coordinator: Chensheng Pan, M.D.
- Email: pancs29@gmail.com
- Phone: +8618202738845
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Stroke, Myocardial Injury, Heart Failure, Acute Coronary Syndromes, Arrhythmia, Sudden Cardiac Death, Takotsubo Syndrome, Heart Rate Variability