Condition

Tetralogy of Fallot clinical trials and research

• 10Clinical trials
• 7NIH research projects
• 6Countries

Newest Tetralogy of Fallot clinical trials

All recruiting trials (10)

• High intensity interval training for patients with congenital heart defects

  This study is testing if a 12-week home workout program can help young people with certain heart defects exercise better and feel stronger.

  Recruiting Erasmus Medical Center · Nijmegen, Gelderland and 1 other locations · NCT06771687

• Effects of stenting on exercise capacity in patients with certain congenital heart defects

  This study is testing if a procedure to open blocked arteries can help people with certain heart defects, like d-TGA, ToF, and TA, exercise better.

  Recruiting UMC Utrecht · Amsterdam and 3 other locations · NCT05809310

• Registry for patients with repaired Tetralogy of Fallot

  This study is collecting information from patients who have had surgery for Tetralogy of Fallot to see how their hearts are doing over time using special imaging tests.

  Recruiting Azienda Ospedaliero, Universitaria Ospedali Riuniti · Ancona, The Marches · NCT05288894

• How transcatheter pulmonary valves interact with electrical pathways in repaired Tetralogy of Fallot

  This project will test if detailed right-ventricular electrical mapping before transcatheter pulmonary valve replacement can find conduction isthmuses that might be 'jailed' and linked to ventricular tachycardia in people with repaired Tetralogy of Fallot.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT05236153

• Understanding heart issues in patients with congenital heart disease

  This study is trying to understand what causes symptoms like shortness of breath and palpitations in people with congenital heart disease, especially those with Tetralogy of Fallot, by using remote heart monitoring.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05122962

• Using beta-blockers to promote heart muscle cell growth in infants with congenital heart defects

  This study is testing if a heart medication called Propranolol can help heart muscle cells grow better in infants with certain congenital heart defects.

  Recruiting at 4 sites Phase 1 Weill Medical College of Cornell University · New York, New York and 3 other locations · NCT04713657

• Monitoring oxygen levels in newborns with congenital heart defects

  This study is testing a new way to monitor oxygen levels in newborns with congenital heart defects to see how it can help doctors understand their heart and blood flow better.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04106479

• Comparing early and late pulmonary valve replacement in children with Tetralogy of Fallot

  This study is testing whether replacing the pulmonary valve earlier or later in children with Tetralogy of Fallot can lead to better heart health and fewer problems down the road.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Aarhus and 2 other locations · NCT04084132

• Registry of patients with Tetralogy of Fallot using implantable defibrillators

  This study is creating a national registry to track adult patients in France with Tetralogy of Fallot who have implantable defibrillators, to better understand their health over time.

  Recruiting Paris Sudden Death Expertise Center · Paris · NCT03837574

• Characterizing heart tissue development in infants with congenital heart disease

  This study looks at heart tissue from infants with congenital heart disease to see how it works differently than in adults, hoping to find better treatments for these conditions.

  Recruiting Emory University · Atlanta, Georgia · NCT00243776

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Why repaired Tetralogy of Fallot can cause heart rhythm problems and low exercise capacity

  This project looks at whether rising pressure in the right atrium leads to arrhythmias and worse exercise ability in adults who had Tetralogy of Fallot repaired.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11134442

• Using beta-blockers to help heart cells grow in children with Tetralogy of Fallot

  This study is looking at how a type of medicine called beta-blockers might help heart muscle cells grow in children with Tetralogy of Fallot, a heart condition they were born with, to better understand how to improve their heart function after surgery.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11080369

• Using AI to predict heart function in patients with repaired tetralogy of Fallot

  This study is looking to make it easier for people who have had surgery for tetralogy of Fallot to understand their heart health by using advanced technology to analyze heart tests, so they can avoid extra MRIs and get better care.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11055102

• New MRI techniques to predict heart issues in patients with tetralogy of Fallot

  This study is looking to help people who have had surgery for tetralogy of Fallot by using special heart scans to better predict serious heart problems, so doctors can know when to step in and provide the right care.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11011367

• Evaluating heart function in adults with tetralogy of Fallot

  This study is looking at how well the hearts of adults who had surgery for tetralogy of Fallot are working, using a new type of CT scan to find any problems that regular tests might miss, so we can help improve their care and health in the long run.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11004602

• Understanding heart issues in patients with repaired tetralogy of Fallot

  This study is looking at why some people who have had surgery for tetralogy of Fallot experience heart rhythm problems and trouble with exercise, and it hopes to find out if fixing a specific heart valve early on can help them feel better and live longer.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10908524

• Understanding heart changes in children with Tetralogy of Fallot

  This study looks at how the hearts of children with Tetralogy of Fallot change over time, especially the right ventricle, to help doctors find out which kids might need extra care after their surgery.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10897232

Related topics

Quick answers

How many Tetralogy of Fallot clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (4 trials), Netherlands (2 trials), Denmark (1 trial), France (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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