Investigating the link between certain blood mutations and sudden cardiac death risk
Official title: Clonal Hematopoeisis of Indeterminate Potential and Risk of Autopsy-defined Sudden Cardiac Death
Funded at University of California, San Francisco · NIH-10995306 · Data updated 2026-11-12
This study is looking at how certain blood cell mutations, known as clonal hematopoiesis of indeterminate potential (CHIP), might raise the risk of serious heart problems, including sudden cardiac death, by examining genetic changes in patients who have passed away.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | December 1, 2021 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $715,276 |
| NIH project number | 5R01HL157247-04 |
| Project ID | NIH-10995306 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with identified mutations associated with clonal hematopoiesis and those at risk for cardiovascular diseases.
✕Less likely to help
Patients without the relevant blood mutations or those who do not have cardiovascular risk factors may not benefit from this research.
What this research studies
This research focuses on clonal hematopoiesis of indeterminate potential (CHIP), a condition where specific blood cell mutations may increase the risk of serious cardiovascular events, including sudden cardiac death. By analyzing genetic mutations in blood cells and their association with sudden cardiac death, the study aims to understand how these mutations contribute to heart disease and mortality. The research utilizes a large cohort of patients who have undergone autopsy to accurately determine the causes of sudden cardiac death, providing a comprehensive view of the relationship between CHIP and cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and preventive strategies for individuals with specific blood mutations, potentially reducing the incidence of sudden cardiac death.
How similar studies have gone: Previous research has shown a significant association between CHIP mutations and increased cardiovascular risks, indicating that this approach is based on established findings.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Tseng, Zian H — University of California, San Francisco
- Study coordinator: Tseng, Zian H
Related research
Other NIH-funded projects on the same topics.
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Imaging-Enhanced Prediction of Sudden Cardiac Death Risk in Pediatric Heart Disease
Aims to create a better, non-invasive way to predict which children with hypertrophic cardiomyopathy (HCM) are at risk of sudden death so doctors can choose who truly needs an ICD.
-
Dynamic predictors of sudden cardiac death in people with coronary artery disease
Aims to improve how we predict who is at risk of sudden cardiac death by looking at changes in heart signals over time.
-
KChIP2-JNK2 axis therapy for preventing sudden cardiac death
A new approach targets how heart cells mishandle calcium to reduce dangerous heart rhythms in people at risk of sudden death.
-
Finding why sudden cardiac death happens in dilated cardiomyopathy and how to stop it
Looks at whether genetics and heart scarring can predict and help prevent deadly heart rhythms in people with dilated cardiomyopathy.
-
Clonal blood-cell mutations and sudden cardiac death risk
This project looks for a connection between clonal blood-cell mutations (CHIP) and sudden cardiac death in adults.
-
Targeting a specific pathway to prevent sudden cardiac death in heart failure patients
This study is looking at a specific pathway in the heart to see if it can help reduce the risk of sudden cardiac death in people with heart failure, and it hopes to find new treatments to manage dangerous heart rhythms that can happen with this condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.