Identifying risk factors for sudden cardiac death

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify potential indicators for pre-warning of sudden cardiac death (SCD) by evaluating various clinical biochemistry markers, electrocardiogram results, echocardiography, MRI, CT imaging values, and genetic markers. The goal is to construct a multi-parameter assessment system for early screening of SCD risk. By including subjects with cardiovascular diseases, the study will collect relevant data to develop and refine an SCD pre-warning score system, ultimately aiming to improve early detection and prevention strategies for at-risk patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

The subjects with the following diagnosis of one or more cardiovascular diseases:

1. Coronary heart disease If there is a history of coronary heart disease or a new diagnosis of coronary heart disease, or with a report of coronary angiography that indicates at least one vascular stenosis\>50%. Diagnosis includes chronic coronary syndrome (stable angina, ischemic cardiomyopathy, and occult coronary heart disease) and acute coronary syndrome (unstable angina, ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction).
2. Heart failure Individuals with a history of heart failure or newly diagnosed heart failure, including heart failure with reduced ejection fraction (HFrEF, left ventricular ejection fraction (LVEF) ≤40%)、intermediate heart failure (HFmrEF, LVEF 41%-49%，with evidence of spontaneous or excitable increase in left ventricular filling pressure), and ejection fraction preserving heart failure (HFpEF, LVEF≥50%, there is evidence of spontaneous or excitable increase in left ventricular filling pressure).
3. Genetically related cardiomyopathy or arrhythmia Cardiomyopathy includes hypertrophic cardiomyopathy (DCM), dilated cardiomyopathy (HCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), inflammatory cardiomyopathy (myocarditis, sarcoidosis, Chagas disease). Hereditary arrhythmias include long QT syndrome, short QT syndrome, Brugada syndrome, idiopathic ventricular fibrillation, catecholamine sensitive polymorphic ventricular tachycardia (CPVT), early repolarization syndrome, etc.

2\) Sign an informed consent form.

Exclusion Criteria:

1. Age\<16 years old;
2. Refusal to the follow-up visits;
3. Individuals with severe mental disorders who are unable to express their wishes;
4. Other obvious physical diseases and abnormal laboratory test results;
5. Patients deemed unsuitable for participation in this study by the supervising physician.

Where it's running

• Sun Yat-sen Memorial Hospital of Sun Yat-sen University
  Guanzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Jingfeng Wang, M.D.,Ph.D. — Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
• Study coordinator: Yuling Zhang, M.D.,Ph.D.
• Email: zhyul@mail.sysu.edu.cn
• Phone: +862081332360

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.