KChIP2-JNK2 axis therapy for preventing sudden cardiac death

Who could benefit from this research

What this research studies

This project investigates how the KChIP2 and JNK2 pathways contribute to dangerous heart rhythms in heart failure, with the goal of identifying a therapy that can prevent sudden death. By studying how Ca2+ handling in heart cells goes awry and how JNK2 influences this process, researchers aim to find a targeted intervention that reduces arrhythmias. The work combines detailed molecular studies with cardiac cell models to uncover a treatment strategy that could complement existing therapies for heart failure patients. If successful, this could lead to new options beyond devices like ICDs for preventing sudden cardiac death.

Why it matters

Where this research is happening

• Ohio State University
  Columbus, United States Active

Researchers

• Principal investigator: Deschenes, Isabelle — Ohio State University
• Study coordinator: Deschenes, Isabelle

Related research

Other NIH-funded projects on the same topics.

• Imaging-Enhanced Prediction of Sudden Cardiac Death Risk in Pediatric Heart Disease

  Aims to create a better, non-invasive way to predict which children with hypertrophic cardiomyopathy (HCM) are at risk of sudden death so doctors can choose who truly needs an ICD.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11393844

• Dynamic predictors of sudden cardiac death in people with coronary artery disease

  Aims to improve how we predict who is at risk of sudden cardiac death by looking at changes in heart signals over time.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11366828

• Finding why sudden cardiac death happens in dilated cardiomyopathy and how to stop it

  Looks at whether genetics and heart scarring can predict and help prevent deadly heart rhythms in people with dilated cardiomyopathy.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11292375

• Clonal blood-cell mutations and sudden cardiac death risk

  This project looks for a connection between clonal blood-cell mutations (CHIP) and sudden cardiac death in adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11231246

• Targeting a specific pathway to prevent sudden cardiac death in heart failure patients

  This study is looking at a specific pathway in the heart to see if it can help reduce the risk of sudden cardiac death in people with heart failure, and it hopes to find new treatments to manage dangerous heart rhythms that can happen with this condition.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11162447

• Understanding the causes of sudden cardiac death in patients with dilated cardiomyopathy.

  This study is looking at how certain genetic factors and heart changes can help doctors find out which patients with dilated cardiomyopathy are at risk for serious heart problems, so they can create better treatments and prevention plans for them.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11047759

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.