Condition

Coronary Arterial Disease (CAD) clinical trials and research

• 47Clinical trials
• 31Countries

Newest Coronary Arterial Disease (CAD) clinical trials

All recruiting trials (47)

• Red grape juice and metabolism in men with coronary disease

  Researchers will test whether daily red grape juice changes the blood metabolite profile in men with chronic coronary artery disease.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07777341

• Edoxaban vs. Apixaban in AF with CAD: Net Benefit

  This trial tests whether edoxaban-based therapy provides a similar or better overall benefit than apixaban-based therapy for stroke prevention and major bleeding in adults with atrial fibrillation and coronary artery disease.

  Recruiting Phase 4 Samsung Medical Center · Seoul · NCT07753200

• Revascularization of Calcified Coronary Arteries

  This study tests whether measuring blood flow and pressure before and after ballooning or stenting of calcified coronary arteries can help predict how well the procedure will work for adults with heart disease.

  Recruiting Aalborg University Hospital · Aalborg · NCT07724184

• OPN Balloon Use for Recanalization of Calcified Coronary Lesions

  This registry tests how the SIS-OPN balloon is used in real-world patients with calcified coronary disease who have undergone PCI in North America.

  Recruiting Minneapolis Heart Institute Foundation · Minneapolis, Minnesota · NCT07646444

• Pulse IVL to open calcified coronary vessels in CAD

  A small, early feasibility study tests the Pulse Intravascular Lithotripsy system in adults with coronary artery disease to see if it can safely open calcified arteries and improve vessel compliance.

  Recruiting at 4 sites Amplitude Vascular Systems, Inc. · Sydney, New South Wales and 3 other locations · NCT07510438

• Crystalline sirolimus-coated balloon for treating coronary artery disease

  This tests whether a crystalline sirolimus-coated balloon is safe and effective for adults having percutaneous coronary intervention for coronary artery blockages or in-stent restenosis.

  Recruiting Fundación Interhospitalaria para la Investigación Cardiovascular FIC · Vigo, Pontevedra · NCT07444957

• Predicting sudden cardiac arrest risk in people with coronary artery disease

  This project will try to see if combining genetics, ECGs, blood biomarkers, imaging, and psychosocial information can predict which people with coronary artery disease are most likely to have sudden cardiac arrest.

  Recruiting at 3 sites Tampere Heart Hospital · Hadera and 2 other locations · NCT07444931

• Using the Supira percutaneous ventricular assist device during and after high-risk PCI

  This study will try the Supira percutaneous ventricular assist device to give extra heart support during and after high-risk PCI for patients with heart failure and reduced ejection fraction.

  Recruiting at 2 sites Supira Medical · Tbilisi, K'alak'i T'bilisi and 1 other locations · NCT07407816

• Combining a drug-coated balloon and a drug-eluting stent for people with diabetes and new coronary artery blockages

  This trial tests whether using a drug-coated balloon together with a drug-eluting stent works better than using either device alone for adults with diabetes who have new (de novo) coronary artery lesions.

  Recruiting Royal College of Surgeons, Ireland · Dublin, County Dublin · NCT07303439

• Cangrelor dose adjustment using platelet testing for patients awaiting coronary procedures

  This trial tests whether adjusting the cangrelor infusion based on platelet-function testing keeps platelet reactivity in the target range for adults with coronary artery disease awaiting coronary procedures.

  Recruiting Phase 4 University of Florida · Jacksonville, Florida · NCT07225842

• Algae supplements for heart risk markers and gut health

  This trial will test whether daily supplements of spirulina or Gelidium corneum change gut microbes and improve heart‑disease risk markers in adults over 50 with cardiovascular disease, diabetes, or related conditions.

  Recruiting Universidade do Porto · Porto · NCT07173062

• No-touch ascending aorta approach during minimally invasive coronary bypass

  This tests whether a 'no-touch' way of handling the ascending aorta during minimally invasive coronary bypass keeps bypass grafts open as well as conventional off-pump bypass for people who need coronary artery bypass surgery.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality · NCT07172620

• Sivelestat sodium treatment after off-pump coronary artery bypass grafting (OPCABG)

  This trial will test whether giving sivelestat sodium after off-pump coronary bypass surgery helps protect the heart and reduce inflammation in adults having OPCABG.

  Recruiting Phase 2 Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT07118930

• Comparing super high-pressure balloon and intravascular lithotripsy to prepare severely calcified coronary arteries

  This trial tests whether a super high-pressure balloon works as well as intravascular lithotripsy to prepare severely calcified coronary lesions in adults getting drug-eluting stents.

  Recruiting at 3 sites Nanjing First Hospital, Nanjing Medical University · Lianyungang, Jiangsu and 2 other locations · NCT07093788

• Shockwave therapy to improve leg wound healing after no-touch saphenous vein harvesting for coronary bypass

  This trial will test whether applying shockwave therapy to the leg incision right after no-touch saphenous vein harvesting can reduce wound healing problems in adults having coronary artery bypass grafting.

  Recruiting Medical University Innsbruck · Innsbruck, Tyrol · NCT07068776

• Adding Compound Danshen and Qishen Yiqi pills for older adults with ongoing angina after standard heart treatment

  This study will test whether adding two traditional Chinese medicine pills (Compound Danshen Dripping Pill and Qishen Yiqi Dripping Pill) helps people aged 75–89 who still have angina after standard medical treatment.

  Recruiting Phase 4 China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07041359

• Switching from clopidogrel to low-dose prasugrel after PCI in people at high bleeding and ischemic risk

  We will test whether switching adults who had PCI and are at both high bleeding and ischemic risk from standard-dose clopidogrel to low-dose prasugrel lowers platelet reactivity compared with staying on clopidogrel.

  Recruiting Phase 4 University of Florida · Jacksonville, Florida · NCT07025148

• Plasma NT‑proBNP and the extent of coronary artery disease

  This project tests whether a blood NT‑proBNP level can indicate how much coronary artery disease someone referred for elective coronary angiography has.

  Recruiting IRCCS Ospedale San Raffaele · Milan, Italy and 1 other locations · NCT07013344

• Contactless vibrometer pulse‑wave test for heart and artery health

  This pilot will try a contactless laser‑Doppler vibrometry and microwave radar device (Cardio P4) in people aged 58–72 to see if it can detect arterial stiffness and signs of coronary artery disease, aortic stenosis, or heart failure.

  Recruiting HJN Sverige AB/Neko Health · Stockholm · NCT07001007

• Using Medipixel XA technology for heart artery procedures

  This study is testing a new technology called Medipixel XA to see if it can make heart artery procedures safer and more effective for people with coronary artery disease.

  Recruiting at 6 sites CHA University · Gwangmyeong, Gyeonggi-do and 5 other locations · NCT06985693

• Heart outcomes after drug-eluting balloon treatment for coronary blockages

  This project will see if adults who had coronary angioplasty with drug-eluting balloons have different rates of major heart problems and survival.

  Recruiting Laval University · Québec, Quebec · NCT06972225

• Evaluating heart function and blood flow in patients with coronary artery disease

  This study is trying to see how well the heart works and how blood flows in people with coronary artery disease by using special imaging and stress tests.

  Recruiting Tomsk National Research Medical Center of the Russian Academy of Sciences · Tomsk · NCT06969547

• AGENT drug-coated balloon versus standard PCI for de novo coronary lesions

  This trial tests whether the AGENT drug-coated balloon is a safe and effective alternative to drug-eluting stents or standard balloon angioplasty for adults with new (de novo) coronary artery lesions undergoing PCI.

  Recruiting at 69 sites Boston Scientific Corporation · Scottsdale, Arizona and 70 other locations · NCT06959524

• Combining CT Angiography and Perfusion for Heart Disease Assessment

  This study is testing if using a combination of advanced heart imaging techniques can help doctors better understand and treat people with coronary artery disease.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT06949150

• Using cold therapy inside coronary arteries to stabilize high‑risk plaque in people with angina or recent heart attack

  This trial will try a device that delivers cold inside a coronary artery to see if it reduces dangerous plaque in people with symptomatic coronary artery disease (stable angina or recent acute coronary syndrome).

  Recruiting Cryotherapeutics SA · Aalst and 2 other locations · NCT06939374

• Comparing two techniques for treating complex coronary bifurcation lesions

  This study is testing two different ways to treat complex heart artery blockages to see which one helps patients feel better and have fewer heart problems after the procedure.

  Recruiting at 2 sites Istanbul Mehmet Akif Ersoy Educational and Training Hospital · Istanbul and 1 other locations · NCT06931574

• Orticumab to reduce coronary artery inflammation after a heart attack

  This tests whether orticumab can reduce coronary artery inflammation over six months in people who had a heart attack and show high inflammation on coronary CT angiography.

  Recruiting at 39 sites Phase 2 Abcentra · Los Angeles, California and 40 other locations · NCT06927739

• Optimal stent deployment strategy for thinner-strut bioresorbable scaffolds guided by intracoronary imaging

  This study tests whether using a thinner-strut bioresorbable scaffold with OCT/IVUS imaging guidance improves outcomes in adults with stable CAD undergoing PCI.

  Recruiting Albert Schweitzer Ziekenhuis, Netherlands · Dordrecht · NCT06919562

• Reduced-dose prasugrel alone after PCI in acute and chronic coronary syndrome

  This test tries whether taking a low 5 mg daily dose of prasugrel alone after a successful PCI can prevent clots while lowering bleeding risk in people with acute or chronic coronary syndromes.

  Recruiting Phase 4 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06916520

• Drug-coated balloons for different types of coronary artery disease

  This registry will try drug-coated balloons as an alternative or addition to stents in people with coronary artery disease to see if they work well and last over time.

  Recruiting at 5 sites Kutahya Health Sciences University · Denizli and 4 other locations · NCT06915597

• AI detection of hidden coronary occlusions and timing of treatment for heart attacks

  This project tests whether an AI reading of 12‑lead ECGs can find hidden coronary occlusions in adults with suspected non‑ST‑elevation ACS and whether the time to PCI after that detection relates to troponin peak levels.

  Recruiting Azienda Ospedaliera di Bolzano · Bolzano, BZ · NCT06910436

• Comparing plasma proteins and metabolites in coronary artery disease patients

  This study is trying to find new blood markers in people with different types of coronary artery disease to see if they can help predict heart problems and lead to better treatments.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06900270

• Nationwide cohort of elderly patients with coronary heart disease in China

  This study is trying to gather health information from older patients with coronary heart disease in China to help improve their treatment and predict their health risks better.

  Recruiting Beijing Hospital · Beijing, Beijing Municipality · NCT06880575

• Impact of Cardiac Rehabilitation on DNA Damage and Inflammation in Heart Disease Patients

  This study is testing if cardiac rehabilitation can reduce DNA damage and inflammation in people with coronary artery disease to help improve their heart health.

  Recruiting TC Erciyes University · Kayseri · NCT06867926

• Comparing two types of drug-coated balloons for heart artery treatment

  This study tests whether sirolimus-coated balloons work better and are safer than paclitaxel-coated balloons for treating heart artery blockages in patients undergoing angioplasty.

  Recruiting Fundacin Biomedica Galicia Sur · Vigo, Pontevedra · NCT06866756

• Beta-blockers to improve coronary blood flow and resistance in people with angina and no blocked coronary arteries

  This trial will see if a beta-blocker (metoprolol) helps people with angina but no obstructive coronary arteries by improving coronary blood flow and lowering small-vessel resistance compared with a placebo.

  Recruiting Phase 4 VZW Cardiovascular Research Center Aalst · Aalst, Flanders · NCT06864234

• Preventive stenting for vulnerable coronary plaques in ACS patients

  This trial will test whether adding a preventive percutaneous intervention to optimal medical therapy helps people with acute coronary syndrome who have non-flow-limiting vulnerable coronary plaques.

  Recruiting Phase 4 Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT06855537

• Sirolimus-coated versus paclitaxel-coated balloon treatment for new coronary bifurcation blockages

  This trial tests whether a sirolimus-coated balloon works better and is as safe as a paclitaxel-coated balloon for adults aged 18–80 with new (de novo) coronary bifurcation blockages.

  Recruiting BrosMed Medical Co., Ltd · Lanzhou, Gansu · NCT06822712

• Identifying risk factors for sudden cardiac arrest in coronary artery disease patients

  This study is trying to find out what clinical and genetic factors might increase the risk of sudden cardiac arrest in people with coronary artery disease.

  Recruiting Tampere Heart Hospital · Tampere, Pirkanmaa · NCT06804499

• Using a chest tube to reduce heart rhythm issues after heart surgery

  This study is testing if using a special chest tube after heart surgery can help reduce the chances of patients developing heart rhythm problems like atrial fibrillation.

  Recruiting Region Skane · Lund · NCT06800781

• Evaluating plaque progression in coronary artery disease using advanced imaging techniques

  This study is testing how advanced imaging can help us understand the growth of plaque in the arteries of people with coronary artery disease over five years and how different factors and treatments affect their heart health.

  Recruiting at 2 sites Ruijin Hospital · Shanghai and 1 other locations · NCT06794684

• Integrated care for older patients with atrial fibrillation

  This study is testing a new team-based care approach for older patients with atrial fibrillation and other health issues to see if it helps them manage their condition better than regular care.

  Recruiting at 50 sites Heart Care Foundation · Haskovo and 49 other locations · NCT06775028

• Comparing orbital atherectomy and intravascular lithotripsy for calcified coronary nodules

  This pilot trial will see if orbital atherectomy or intravascular lithotripsy better prepares OCT-identified calcified coronary nodules for stent placement in adults with coronary artery disease.

  Recruiting at 6 sites Spanish Society of Cardiology · Alicante, Alicante and 5 other locations · NCT06736665

• Evaluating ShockPulse-10 for treating coronary artery calcification

  This study is testing a new treatment called ShockPulse-10 to see if it can safely help people with serious coronary artery calcification who are getting stents.

  Recruiting Keya Medical · Beijing, Beijing Municipality · NCT06711822

• Inspiratory muscle training for heart disease patients after angioplasty

  This study tests whether a special breathing exercise program can help heart disease patients feel better and exercise more after having angioplasty.

  Recruiting University of Cadiz · Málaga · NCT06681740

• Using Shockwave technology to treat calcified coronary artery disease

  This study is testing a new shockwave treatment to see if it can safely help people with hard, calcified arteries feel better before they get stents.

  Recruiting at 34 sites Shockwave Medical, Inc. · La Jolla, California and 33 other locations · NCT06662500

• Comparing antiplatelet therapies after heart procedures

  This study is testing whether a new way of managing blood-thinning medications after heart procedures can help people with heart issues avoid problems while also reducing the risk of bleeding.

  Recruiting Phase 4 University of Florida · Jacksonville, Florida · NCT06588595

Related topics

Quick answers

How many Coronary Arterial Disease (CAD) clinical trials are recruiting right now?

47, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 31 countries. The most sites are in China (11 trials), Spain (7 trials), United States (7 trials), Italy (4 trials), South Korea (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 8, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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