How PrEP Drugs Affect HIV Risk in Women and Reproductive Health
Official title: Effects of PrEP Drugs on Female Genital HIV Infection and Women's Reproductive Health
Funded at University of Nevada Reno · NIH-11528077 · Data updated 2026-11-12
This project looks at how PrEP medicines work for women, and whether they influence pregnancy-related processes in the uterus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | April 15, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $599,720 |
| NIH project number | 7R00HD110319-04 |
| Project ID | NIH-11528077 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women of reproductive age using or considering PrEP, including those with sub-fertile conditions (endometriosis, PCOS, uterine fibroids).
✕Less likely to help
Women outside the target age range or not considering PrEP use may not directly benefit.
What this research studies
The study focuses on how the female reproductive tract affects PrEP effectiveness and whether PrEP has any impact on endometrial functions important for pregnancy. Researchers will explore factors like vaginal balance and genital inflammation that could change PrEP performance. They will also examine potential effects in sub-fertile women with conditions such as endometriosis, PCOS, or fibroids. The goal is to understand how PrEP and female reproductive biology interact so women can make informed choices about HIV prevention and pregnancy planning.
Why it matters
Potential benefit: If successful, this research could improve PrEP effectiveness for women and clarify safety for pregnancy-related processes.
How similar studies have gone: Previous work has shown variable PrEP efficacy in women and raised questions about mucosal biology and fertility, with some similar lines of research indicating important interactions.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: George, Ashley F — University of Nevada Reno
- Study coordinator: George, Ashley F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.