Healthy Families-PrEP: helping pregnant and new mothers in Uganda stay HIV-free
Official title: Evaluating Healthy Families PrEP: an intervention to promote PrEP use during periconception, pregnancy, and postpartum periods for women in rural Uganda
Funded at Yale University · NIH-11473991 · Data updated 2026-11-12
A family-focused program in Uganda tests an approach to help women who are planning pregnancy or are pregnant or postpartum use PrEP to prevent HIV infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 10, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $396,627 |
| NIH project number | 7R01MH134680-02 |
| Project ID | NIH-11473991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women in Uganda who are periconception, pregnant, or postpartum and are at risk for HIV, especially those considering PrEP.
✕Less likely to help
Women not considering PrEP, or those without HIV risk factors or access to PrEP may not benefit.
What this research studies
This project adapts and tests a three-session intervention that supports periconception, pregnancy, and postpartum women in Uganda in using PrEP. Participants receive counseling on safe conception and HIV prevention, are offered PrEP, and receive quarterly adherence support. The study builds on prior pilot data showing strong initiation and adherence among women in HIV care clinics, with measurements of medication use and protective drug levels over nine months. If successful, the intervention could be scaled to additional settings in Uganda and eventually brought to the United States to reduce perinatal HIV risk.
Why it matters
Potential benefit: If successful, the program could significantly reduce HIV acquisition for pregnant and postpartum women, improving maternal and infant health outcomes.
How similar studies have gone: Pilot data from the 3-session Healthy Families-PrEP intervention showed high PrEP initiation and adherence among participants.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Matthews, Lynn T — Yale University
- Study coordinator: Matthews, Lynn T
Related research
Other NIH-funded projects on the same topics.
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Healthy Families-PrEP: helping women in Uganda start and stay on PrEP during periconception, pregnancy, and postpartum
A program in Uganda helps periconception, pregnant, and postpartum women use PrEP safely to prevent HIV, with support sessions and monitoring.
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Injectable HIV PrEP in maternity clinics to protect pregnant and postpartum women
A doctor-scientist team is testing a twice-yearly injectable HIV prevention medicine for pregnant and postpartum women in high-risk areas to help keep them and their babies HIV-free.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.