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Pediatric Cancer clinical trials and research
As of November 12, 2026, Find a Trial lists 63 Pediatric Cancer clinical trials that are recruiting, at sites in 34 countries (most in United States (32), France (8), China (5)). 1 was first registered in the last 30 days. By phase: Phase 1/2 (5), Phase 2 (5), Phase 3 (1), Phase 1 (1). The most active sponsors are Children's Hospital of Philadelphia (6), Sun Yat-sen University (3), St. Jude Children's Research Hospital (2). There are also 26 NIH-funded research projects on Pediatric Cancer, with $16.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 63Clinical trials
- 26NIH research projects
- 1New in 30 days
- 34Countries
Newest Pediatric Cancer clinical trials
All recruiting trials (63)
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FaceSay: a computer program to help kids recognize facial expressions and improve social interactions
A computer-based FaceSay program is tested to see if it helps survivors of pediatric brain tumors who have social difficulties see facial expressions better and relate more comfortably with peers.
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Access to Innovative Cancer Treatments for Children and Young People in Belgium
This observational study collects safety and effectiveness data on off‑label and compassionate cancer medicines used in kids and young adults up to age 25 in Belgium.
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BCB-276 CAR T therapy for DIPG in children and young adults
This study tests BCB-276, a patient's own CAR T cells against DIPG, after standard radiation, to see if it is safe and can help extend survival.
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CAYA cancer patients in LMICs: a forward-looking observation of care and outcomes
This study follows children, teens, and young adults with cancer in low- and middle-income countries to see how routine care affects treatment, access, and outcomes over time.
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Virtual reality headsets to reduce anxiety and fear during intrathecal chemotherapy in children
This project will try virtual reality headsets with children aged 4–10 who are receiving intrathecal chemotherapy to see if they reduce anxiety, fear, and changes in vital signs.
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Laser thermal therapy for young people with low-grade glioma
This research will test whether laser interstitial thermal therapy (LITT) can stop or slow recurrent or progressive low-grade gliomas in children, adolescents, and young adults.
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Thyroid cancer risk and follow-up after childhood radiotherapy
This project will test whether earlier and regular ultrasound plus genetic testing can detect thyroid nodules and cancers sooner in children treated with radiotherapy.
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Self‑report questionnaire to spot inherited cancer risk in children and teens
This project will test whether a caregiver- or patient-completed questionnaire plus a short pre-visit brochure can help identify children and adolescents with an inherited cancer predisposition and improve caregiver genetics knowledge and satisfaction.
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Real-world rehabilitation for children and young adults with cancer in Italy (ReWori)
This project will follow children and young adults with cancer in Italy to see how their physical and motor abilities change while they receive usual physiotherapy or neuropsychomotor rehabilitation.
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Co-designing Spanish videos to explain key pediatric cancer topics
This project will test short Spanish-language educational videos co-created by parents, medical interpreters, and clinicians to help Spanish-speaking caregivers of children with cancer better understand important care topics.
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Cancer Care Companion communication tool for parents
Parents of children newly diagnosed with cancer can try an electronic health-record communication tool called Cancer Care Companion to see if it is acceptable, appropriate, and feasible for supporting care.
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Ondansetron orodispersible film to prevent vomiting during pediatric radiotherapy
This test tries whether a dissolvable ondansetron strip given once or twice can prevent vomiting in children aged 1–14 receiving moderate-emetic-risk radiotherapy.
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Snoezelen multisensory relaxation to reduce anxiety during pediatric chemotherapy hospital stays
This will try Snoezelen multisensory relaxation sessions to see if they reduce anxiety in children and adolescents aged 8–17 hospitalized for chemotherapy.
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Pucotenlimab with lenvatinib and chemotherapy for children with advanced or relapsed hepatoblastoma
This study will test whether pucotenlimab combined with lenvatinib and irinotecan can help children aged 2–18 whose hepatoblastoma did not respond to prior treatments.
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Nalbuphine versus tramadol for post-operative pain after abdominal surgery in children with cancer
This trial tests whether nalbuphine or tramadol better controls pain after abdominal surgery in children aged 3–12 with cancer.
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Improving communication about sexual health for young cancer patients
This study is testing a new online tool to help young cancer patients talk more openly with their doctors about sexual and reproductive health.
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LOG-AFTER software to improve long-term monitoring of childhood cancer survivors
This project will test whether giving childhood cancer survivors access to the LOG-AFTER app (with optional GP linkage) helps them follow recommended long-term screenings.
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Impact of massage therapy on sleep in young cancer patients
This study is testing whether personalized massage therapy can help young cancer patients in the hospital sleep better and feel less tired, anxious, and in pain during their treatment.
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Understanding coping strategies in children with cancer and their parents
This study looks at how children with cancer and their parents handle the illness together to see what helps them cope better during treatment.
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Stratified treatment for pediatric rhabdomyosarcoma based on risk factors
This study is testing a new treatment plan for children with rhabdomyosarcoma to see if combining chemotherapy and radiotherapy helps improve survival based on their risk levels.
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Video-based discussion tool to help families of kids with cancer talk about goals of care
A video-based intervention (VIDEO-PEDS) is tested to see if it helps clinicians and parents of children with cancer better document and decide on goals of care and end-of-life plans.
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Using chlorhexidine dressings to prevent infections in pediatric cancer patients with catheters
This study is testing if using special dressings with chlorhexidine can help prevent infections in young cancer patients who have catheters.
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Understanding recovery in children after cancer surgery
This study looks at how children aged 3-18 and their families recover after cancer surgery by using smartwatches and surveys to gather information over a year.
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Helping parents and children with cancer make treatment decisions
This study is trying to see if giving parents and their kids with cancer better information can help them make treatment decisions together.
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Testing a new antibody treatment for advanced solid tumors and liver cancer
This study is testing a new antibody treatment for people with advanced solid tumors and liver cancer to see if it is safe and how well it works.
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Using AI to diagnose melanoma in young patients
This study is testing if artificial intelligence can help doctors better identify melanoma in children and young adults by looking at skin images.
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Treatment for RET Fusion Thyroid Cancer in Young Patients
This study is testing a new treatment combining selpercatinib and radioactive iodine for children and young adults with a specific type of thyroid cancer to see if it helps improve their condition after surgery.
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Combining Pucotenlimab with standard chemotherapy for pediatric rhabdomyosarcoma
This study is testing if adding a new drug called Pucotenlimab to standard chemotherapy can help children and teens with a type of cancer called rhabdomyosarcoma.
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A program to develop new treatment strategies for pediatric cancer patients with limited options
This study is testing a new program that brings together experts to find better treatment options for kids with cancer who have few choices left.
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Emotion and Symptom-Focused Engagement (EASE) for parents of children with cancer
This trial will test whether adding the EASE psychotherapy to usual care helps parents of children newly diagnosed or relapsed with cancer have fewer traumatic stress symptoms over six months.
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Telehealth therapy for parents of children with cancer
This study is testing whether online therapy can help parents of young children with cancer improve their parenting skills and emotional well-being.
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Feasibility of the PediRISE program for families of children with cancer
This study is testing a support program for families of children recently diagnosed with cancer who are struggling financially to see if it helps them better than regular care.
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Using guided imagery to reduce nausea and vomiting in children undergoing chemotherapy
This study is testing if using guided imagery can help reduce nausea and vomiting in children aged 7 to 18 who are receiving chemotherapy.
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Using arsenic trioxide with chemotherapy to treat pediatric cancer with p53 mutations
This study is testing if adding arsenic trioxide to chemotherapy can help children with Li-Fraumeni syndrome and p53 mutations fight their cancer more safely.
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Peer navigation support for Hispanic parents of children with cancer
This study tests whether having trained peer supporters can help Hispanic parents of children with cancer get involved in clinical trials better than standard care.
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Analyzing how individual children respond to radiation in cancer treatment
This study is testing how different children react to radiation during cancer treatment to help doctors give safer and more effective care.
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Using lurbinectedin to treat specific tumors in children and young adults
This study is testing if a new drug called lurbinectedin can help children and young adults with certain types of tumors, like Ewing sarcoma, by targeting the proteins that make the tumors grow.
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Using Larotrectinib to Improve Radioactive Iodine Treatment in Thyroid Cancer
This study is testing if adding a drug called larotrectinib to radioactive iodine treatment can help people with a specific type of thyroid cancer that has spread to the lungs feel better.
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Training program to improve attention in childhood cancer survivors
This study is testing if a special video game can help improve attention and thinking skills in kids aged 8-16 who have survived leukemia or brain tumors.
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Screening for sexual dysfunction in young cancer survivors
This study is trying out a new way to check for sexual problems in young cancer survivors aged 15-24 to help doctors better understand and support their needs.
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Observing genetic factors in Indian children with leukemia
This study looks at how genetic differences might affect side effects from chemotherapy in Indian children with leukemia to see how it impacts their quality of life.
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Combining cyclophosphamide, sorafenib, bevacizumab, and atezolizumab for children and young adults with relapsed solid tumors
This will test whether giving atezolizumab and bevacizumab every three weeks together with daily cyclophosphamide and dose‑adjusted sorafenib is safe and can shrink relapsed or hard‑to‑treat solid tumors in children and young adults, including fibrolamellar carcinoma.
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Evaluating how pediatric cancer patients respond to the flu vaccine
This study is testing how well the flu vaccine works in children with cancer to see if it helps them build immunity against the virus.
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Exercise program for children with cancer to improve insulin sensitivity
This study is testing if an exercise program can help improve insulin sensitivity and overall health in children with cancer.
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Freezing ovarian tissue to preserve fertility in young cancer patients
This study is testing whether freezing ovarian tissue can help young cancer patients preserve their fertility for the future after they undergo treatments like chemotherapy or radiation.
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eHealth support for parents of children with cancer
This study is testing a new online support program for parents of children with cancer to see if it can help them feel less stressed and more able to cope.
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Donation of pediatric tumor tissues and cells after death
This study is trying to collect tumor tissues and cells from children who have passed away to help create better models for studying pediatric cancers and testing new treatments.
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Registry for childhood and young adult cancer patients
This study is creating a registry for young cancer patients to track their health and well-being over time and help improve future care.
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Exercise program for children and young adults with cancer
This study tests if a structured exercise program can help children and young adults with cancer feel better physically and emotionally while they are undergoing treatment.
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Targeted therapy to improve radioactive iodine uptake in metastatic thyroid cancer
This study is testing if a targeted therapy can help improve how well radioactive iodine works on lung tumors in patients with advanced thyroid cancer.
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Online physical activity program for children and adolescents with cancer
This study tests an online exercise program for kids and teens with cancer to see if it helps them feel better during their treatment.
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Evaluating immune response to vaccines in pediatric cancer survivors
This study tests how well booster vaccines or full revaccination help improve the immune response in kids who have survived cancer compared to their healthy siblings.
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Using virtual reality to reduce stress in children undergoing proton therapy
This study is testing whether using virtual reality can help reduce stress and anxiety in children receiving proton therapy for cancer treatment.
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Collecting data and specimens from pediatric cancer patients
This study is collecting samples and information from kids with cancer to see how their genes and tumor details can help find better treatments.
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Study on childhood cancer predisposition
This study is trying to learn more about children who have a higher risk of cancer and their families to improve how we monitor and care for them.
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Access to innovative cancer treatments for young patients
This study is trying to gather information on new cancer treatments for kids and young adults who aren't responding to standard therapies to see how safe and effective they are.
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Assessing heart damage in young cancer survivors
This study is trying to find out if heart damage can be detected early in young cancer survivors who received certain chemotherapy treatments, to help prevent future heart problems.
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Registry of Childhood Cancer in Pediatric Oncology Units in French Speaking Africa
This study is collecting information about children with cancer in French-speaking Africa to help improve cancer care and treatment programs for them.
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Hypnosis and self-care intervention for children with cancer and their parents
This study is testing a program that uses hypnosis and self-care techniques to help improve the well-being of children with cancer and their parents.
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Radiotherapy for pediatric cancer using deep inspiration breath-hold technique
This study is testing a breathing technique during radiation therapy to see if it can help protect healthy organs in children with tumors in their chest or abdomen.
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Therapeutic stratification for pediatric cancer patients with relapsed or refractory tumors
This study is testing if targeted cancer treatments can help children and teens with tough-to-treat tumors by using their specific genetic information to guide the best therapy.
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Database for childhood cancer survivors
This study is creating a detailed database to help childhood cancer survivors by collecting health information to improve their long-term well-being and address any late effects from their treatment.
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Camping experience for children with cancer
This study tests whether a camping experience can help children with cancer feel better and build confidence while they are undergoing treatment.
NIH-funded research (26)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Deep profiling of how fusion-driven pediatric cancers spread, using single-cell protein tools
Researchers will develop fast, highly capable single-cell protein measurements to understand how certain pediatric cancers, like Ewing sarcoma, spread and evade the immune system.
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Radiation therapy and data science to help kids with cancer
Scientists from two top cancer centers are teaming up to make radiation for pediatric cancers more powerful and precise, using data science to guide treatment for children with two tough tumors.
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Targeting childhood cancer vulnerabilities with CRISPR-based screens
A pediatric cancer research project uses CRISPR screens to find new, druggable weaknesses in childhood leukemias to guide safer, targeted therapies.
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Genetic links between birth anomalies and childhood cancer in kids and young people
This grant tests how inherited birth defects and genetic factors may increase the risk of cancer in children and teens, using real-world birth and cancer data to understand shared genetics.
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A living-cell detector for ALT-related biomarkers in pediatric bone cancers
A new, cell-based tool will help scientists see ALT activity in cancer cells from pediatric tumors, potentially guiding future therapies.
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Using children's tumor protein and genetic data to find better treatments
This project analyzes tumor DNA, RNA, proteins, and protein modifications to find potential treatment targets for children with brain tumors and leukemias.
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Screening tool to detect sexual dysfunction in pediatric cancer survivors
A clinician-researcher is testing a screening tool to help identify sexual dysfunction in children who survived cancer, with the aim of improving their quality of life.
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Cancer Care Companion: an EHR tool to help parents of children with cancer
This project will build and pilot an Epic MyChart-based Care Companion to help parents of young children with cancer track symptoms, access education, and message clinicians.
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Social and emotional challenges for children who survived cancer early in life
This project looks at how physical problems and thinking/learning difficulties after cancer treatment affect friendships, social life, and emotional wellbeing in people who had cancer as very young children.
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Genetic links between birth defects and childhood cancer
Looking for shared genes that might explain why some children born with birth defects have a higher chance of developing cancer.
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Making radiation safer and more powerful for children with diffuse midline glioma and high‑risk neuroblastoma
This project aims to improve radiation treatments for children with diffuse midline glioma and high‑risk neuroblastoma by using tumor biology and data science to guide therapy.
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Targeting genetic weak spots in childhood cancers
Using lab gene-editing and screening tools to find and block weaknesses in childhood cancers so researchers can develop safer, more precise treatments for kids with leukemias and other pediatric tumors.
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A tool to improve communication and self-management for families dealing with pediatric cancer
This study is creating a helpful online tool called the Cancer Care Companion to improve communication between doctors and parents of kids with cancer, making it easier for families to access information and support.
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Understanding the psychosocial challenges faced by young cancer survivors
This study is looking at how young kids who survived early cancer, especially those who had treatments that impacted their brains, deal with feelings of loneliness and trouble making friends, so we can find better ways to help them feel happier and more connected.
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Understanding how pediatric cancer survivors grow and transition to adult care
This study is looking at how young adults who survived cancer can better manage their health as they move from children's to adult healthcare, focusing on their feelings and experiences to help them live healthier lives and stick to their follow-up care.
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Helping parents promote healthy eating and exercise in pediatric cancer survivors with obesity
This study is helping families of kids aged 5-11 who have survived cancer and are dealing with being overweight or obese by encouraging parents to promote healthy eating and exercise, making it easier for everyone to adopt better habits together.
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Investigating RNA editing in pediatric T-cell leukemia
This study is looking at how changes in RNA might affect the development of T-cell acute lymphoblastic leukemia in kids, with the hope of finding new ways to help them respond better to treatment and improve their chances of survival.
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Improving communication about prognosis for children with advanced cancer
This study is all about helping doctors talk to kids with advanced cancer and their families about what to expect, so they can share important information in a way that feels right for everyone and improve the care these children receive.
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Finding new ways to treat childhood cancers
This study is exploring new ways to treat kids with acute myeloid leukemia (AML) by using cutting-edge techniques to find better and safer medicines, so young patients can have more effective treatments than the usual chemotherapy and radiation.
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Exploring the link between birth defects and childhood cancer
This study is looking at how certain birth defects might raise the chances of kids getting cancer, and it aims to help families understand their health risks better by exploring the genetic links between these conditions.
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Improving radiation treatment for pediatric cancers using advanced data science
This study is looking at how the genes of aggressive childhood tumors, like diffuse midline glioma and high-risk neuroblastoma, affect how well radiation therapy works, so we can create better treatments that are more suited to each child's unique cancer.
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Improving health outcomes for childhood cancer survivors
This study is looking at how kids who have survived cancer can stay healthy and happy as they grow up, and it’s designed to help them overcome any ongoing health challenges they might face.
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Screening tool for sexual dysfunction in childhood cancer survivors
This study is creating a helpful tool to spot sexual health issues in young adults who survived childhood cancer, so they can get the support they need to improve their quality of life and mental well-being.
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Using deep learning to understand how pediatric cancer cells respond to drugs
This study is exploring new ways to treat childhood cancers by using smart computer techniques to see how cancer cells from kids react to different medicines, hoping to find better treatments for young patients.
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Investigating how certain proteins affect the spread of pediatric cancer cells
This study is looking at how certain proteins in Ewing sarcoma, a type of cancer that affects kids, change how the cancer cells act and spread, with the hope of finding new ways to help the immune system fight the cancer.
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Using genetic testing to improve cancer care for children
This study is looking at how genetic testing can help doctors understand the risk of heart problems in kids who have had cancer treatment with certain chemotherapy drugs, so they can create safer and more personalized treatment plans for them.
Related topics
Quick answers
How many Pediatric Cancer clinical trials are recruiting right now?
63, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 34 countries. The most sites are in United States (32 trials), France (8 trials), China (5 trials), Italy (5 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1/2: 5, Phase 2: 5, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.