Condition

Differentiated Thyroid Cancer clinical trials and research

• 10Clinical trials
• 2NIH research projects
• 8Countries

Newest Differentiated Thyroid Cancer clinical trials

All recruiting trials (10)

• Personalized drug combos for advanced thyroid cancer

  This phase Ib study tests whether customized drug combinations, chosen from existing approved medicines based on a patient’s tumor genetics, can be safely given to people with advanced thyroid cancer when standard options are limited.

  Recruiting Phase 1 Radboud University Medical Center · Nijmegen · NCT07485569

• F-18 Tetrafluoroborate PET/CT to find recurrent or residual differentiated thyroid cancer

  This test will see if F-18 Tetrafluoroborate PET/CT finds recurrent or residual differentiated thyroid cancer better than standard F-18 FDG PET/CT in adults who had surgery and radioactive iodine and now have rising thyroglobulin or anti-thyroglobulin.

  Recruiting at 2 sites Ankara University · Ankara, Ankara and 1 other locations · NCT07436455

• Predicting challenges in thyroid surgery

  This study is trying to find out which factors can help doctors predict how challenging thyroid surgery will be for patients with thyroid cancer so they can plan better and keep patients safe.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06671184

• Treatment for RET Fusion Thyroid Cancer in Young Patients

  This study is testing a new treatment combining selpercatinib and radioactive iodine for children and young adults with a specific type of thyroid cancer to see if it helps improve their condition after surgery.

  Recruiting at 3 sites Phase 2 Children's Hospital of Philadelphia · San Francisco, California and 4 other locations · NCT06458036

• Treatment for advanced thyroid cancers using sacituzumab govitEcan

  This study is testing a new drug called sacituzumab govitEcan to see if it can help people with advanced thyroid cancers that don't respond to traditional treatments.

  Recruiting at 9 sites Phase 2 Grupo Espanol de Tumores Neuroendocrinos · Barcelona and 10 other locations · NCT06235216

• Using pembrolizumab to treat high-risk differentiated thyroid cancer before surgery

  This study is testing if the drug pembrolizumab can help people with high-risk thyroid cancer before they have surgery.

  Recruiting Phase 2 Istituti Clinici Scientifici Maugeri SpA · Pavia, Lombardy · NCT05852223

• Using Larotrectinib to Improve Radioactive Iodine Treatment in Thyroid Cancer

  This study is testing if adding a drug called larotrectinib to radioactive iodine treatment can help people with a specific type of thyroid cancer that has spread to the lungs feel better.

  Recruiting at 5 sites Phase 2 Children's Hospital of Philadelphia · San Francisco, California and 5 other locations · NCT05783323

• Comparing hemithyroidectomy and total thyroidectomy for low-risk thyroid cancers

  This study is testing whether a less extensive thyroid surgery is just as effective as a full thyroid removal for people with low-risk thyroid cancer.

  Recruiting at 30 sites University College, London · Crewe, Cheshire and 32 other locations · NCT05604963

• Iodine uptake in thyroid cancer patients after a low iodine diet

  This study is testing whether a low iodine diet for 7 days can help improve how well radioactive iodine is taken up by the thyroid in patients with thyroid cancer who are getting ready for treatment.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT05599139

• Targeted therapy to improve radioactive iodine uptake in metastatic thyroid cancer

  This study is testing if a targeted therapy can help improve how well radioactive iodine works on lung tumors in patients with advanced thyroid cancer.

  Recruiting at 9 sites Children's Hospital of Philadelphia · San Francisco, California and 8 other locations · NCT05024929

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Online support for people with differentiated thyroid cancer after radioactive iodine treatment

  A web-based program to help people with differentiated thyroid cancer manage side effects and improve quality of life after radioactive iodine treatment.

  NIH research Georgetown University · Washington, United States · NIH-11311315

• A web-based support tool for patients with thyroid cancer after treatment

  This study is testing a helpful online tool called iSupport for people with differentiated thyroid cancer who have had radioactive iodine treatment, to provide them with useful information and support to make their recovery easier and improve their quality of life.

  NIH research Georgetown University · Washington, United States · NIH-11231962

Related topics

Quick answers

How many Differentiated Thyroid Cancer clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (3 trials), Netherlands (2 trials), Spain (1 trial), Turkey (Türkiye) (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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