Analyzing how individual children respond to radiation in cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on understanding the individual radiosensitivity of pediatric patients undergoing treatment for various types of cancer, including brain tumors and neuroblastoma. By analyzing blood samples from children and adolescents aged 3 to 18 who are receiving radiotherapy, the research aims to identify factors that influence how patients respond to radiation therapy. The goal is to improve treatment outcomes and minimize radiation toxicity by tailoring therapies based on individual sensitivity. This integrative molecular analysis could lead to more personalized cancer care for young patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Minor patient treated for a brain tumor, Ewing tumor, malignant mesenchymal tumor, neuroblastoma, nephroblastoma, Hodgkin's lymphoma treated with radiotherapy (+/- chemotherapy) for curative purposes.
* Children or adolescents \> 3 years old and \< 18 years old
* Patient with an indication for radiotherapy as part of the primary tumor local control strategy
* Theoretical indication for radiotherapy in standard fractionation (1.8 Gy to 2.2 Gy / fraction: 5 fr/week) whatever the technique and the particle used
* Patient affiliated with a social security scheme
* Patient and/or parents or holders of parental authority having dated and signed an informed consent

Exclusion criteria:

* Patients with contraindications to blood sampling
* Patients with contraindications to radiotherapy
* Palliative radiotherapy
* Patient with previous RT treatment in the same area (re-irradiation)
* Patient with an indication of hypofractionated RT
* Patient follow-up not possible
* Persons deprived of liberty or under guardianship (including curatorship)

Exclusion Criteria:

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Where it's running

• Centre François Baclesse
  Caen, France Recruiting
• Centre Oscar Lambret
  Lille, France Not yet recruiting

Study contacts

• Study coordinator: Sandrine PEREIRA, PhD
• Email: spereira@neolys-diagnostics.fr
• Phone: 0643957510

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.