Investigating RNA editing in pediatric T-cell leukemia
Official title: Profiling Epitranscriptomic RNA editing in Pediatric Cancer
Funded at University of California, San Diego · NIH-10993112 · Data updated 2026-11-12
This study is looking at how changes in RNA might affect the development of T-cell acute lymphoblastic leukemia in kids, with the hope of finding new ways to help them respond better to treatment and improve their chances of survival.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $158,000 |
| NIH project number | 5R03CA287274-02 |
| Project ID | NIH-10993112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with relapsed T-cell acute lymphoblastic leukemia.
✕Less likely to help
Patients with other types of leukemia or those who are not experiencing relapse may not benefit from this research.
What this research studies
This research focuses on understanding how RNA editing, specifically the conversion of adenosine to inosine, affects the development of pediatric T-cell acute lymphoblastic leukemia (T-ALL). By analyzing RNA samples from T-ALL patients, the study aims to identify patterns of RNA editing that may contribute to the disease's progression and resistance to treatment. The researchers will explore the role of a specific enzyme, ADAR1, which has been linked to poor outcomes in T-ALL patients. Ultimately, the goal is to uncover new therapeutic strategies that could improve survival rates for children with this aggressive form of leukemia.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that significantly improve survival rates for children with relapsed T-ALL.
How similar studies have gone: While there has been significant research on RNA editing in adult cancers, this specific focus on pediatric T-ALL is relatively novel and untested.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Jiang, Qingfei — University of California, San Diego
- Study coordinator: Jiang, Qingfei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.