A program to develop new treatment strategies for pediatric cancer patients with limited options

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the effectiveness of the Pediatric Evolutionary Tumor Board (pedsETB), a multidisciplinary and multisite group, in creating additional therapeutic strategies for pediatric cancer patients who are considered likely incurable. The focus is on patients who have newly diagnosed cancer, relapsed, or are in remission but at high risk of recurrence, and who have not responded well to previous treatments. The study aims to gather clinical data and insights from various experts to improve outcomes for these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant must be considered likely incurable given the standard of care. This is inclusive of patients newly diagnosed, relapsed or in remission but at high risk of recurrence, with suboptimal responses to previous therapy, or with many potentially beneficial, but unlikely curative options for care.

The site investigator will make this determination based on their experience.

* Participant must have an age-appropriate performance status: Karnofsky 50 or more for patients 16 years of age or older OR Lansky score of 50 or more for patients less than16 years of age.
* Participant and/or parents or legal guardian and primary oncologist must be willing to consider the therapeutic strategies recommended by the pedsETB.
* Participant must be willing to be followed over time and allow collection of clinical data including scans, available blood and lab samples, and optional pedsETB serial blood sampling.
* All Participants and/or their parents or legal guardians must have the ability to understand and the willingness to sign a written informed consent or assent document.

Exclusion Criteria:

* Participants without known therapies to reliably induce a response are excluded from pedsETB and should seek clinical trials.

Where it's running

• Connecticut Children's Medical Center
  Hartford, Connecticut, United States Recruiting
• University of Miami
  Miami, Florida, United States Recruiting
• Moffitt Cancer Center
  Tampa, Florida, United States Recruiting
• University of Kentucky
  Lexington, Kentucky, United States Recruiting
• Roswell Park Comprehensive Cancer Center
  Buffalo, New York, United States Recruiting

Study contacts

• Principal investigator: Jonathan Metts, MD — Moffitt Cancer Center
• Study coordinator: Jessica Crimella
• Email: Jessica.Crimella@moffitt.org
• Phone: 813-745-6250

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.