Clinical trial Recruiting at 8 sites Observational Ages 0 Months to 24

Real-world rehabilitation for children and young adults with cancer in Italy (ReWori)

Official title: Real World Pediatric Oncology Rehabilitation in Italy (ReWori) Study Protocol: Prognostic Factors of Functional Abilities in Children, Adolescents and Young Adults With Cancer Undergoing Rehabilitation

Run by Associazione Italiana Ematologia Oncologia Pediatrica · NCT07368582 · Data updated 2026-11-12

This project will follow children and young adults with cancer in Italy to see how their physical and motor abilities change while they receive usual physiotherapy or neuropsychomotor rehabilitation.

More Pediatric Cancer trials

Quick facts

Study typeObservational
Ages0 Months to 24 Years
SexAll
Enrollment249 (estimated)
SponsorAssociazione Italiana Ematologia Oncologia Pediatrica
Academic / other
Locations13 sites (Bergamo, Italia and 12 other locations)
StatusRecruiting
StartedJuly 19, 2024
Main results expectedMarch 31, 2029
Study endsSeptember 30, 2029
Registry record updatedMarch 25, 2026
Trial IDNCT07368582 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Children, adolescents, and young adults aged 0–24 with a cancer diagnosis who are referred to rehabilitation services at participating Italian AIEOP hospitals or affiliated rehabilitation centers and who provide consent are ideal candidates.

Probably not a fit

Patients who cannot attend regular rehabilitation visits, who decline consent, or whose medical condition prevents standard physiotherapy may not receive direct benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, observational registry that will collect real-world, longitudinal data on functional abilities in patients aged 0–24 receiving routine physiotherapy or neuropsychomotor rehabilitation across AIEOP centers in Italy. Participants receive usual rehabilitation care and are evaluated on functional outcomes and health-related quality of life at regular intervals, typically monthly, using standardized tools such as the FAAP-O when available. The study documents the types of rehabilitation practices used, rehabilitation needs, and changes in motor performance across different stages of treatment and recovery. Data will be pooled across participating hospitals and rehabilitation centers to describe typical care pathways and outcome trajectories in everyday clinical settings.

Why it matters

Potential benefit: If successful, the project could clarify common rehabilitation pathways and help target therapies to preserve or improve mobility and quality of life for children and young adults with cancer.

How similar studies have gone: Previous research on general physical activity in pediatric oncology suggests some benefit, but high-quality multicenter evidence for targeted physiotherapy or neuropsychomotor rehabilitation is limited, making this larger standardized effort relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of cancer,
* Children, adolescents and young adults aged between 0 and 24 years old,
* Children, adolescents and young adults at any stage of treatment and off therapy,
* Children, adolescents and young adults referred to the Rehabilitation Service of AIEOP centres and Rehabilitation Centres that provide rehabilitation care for paediatric and young adult cancer patients involved in the study.

Exclusion Criteria:

* Failure to sign the consent/assent form for participation in the study by the subject and/or by the person exercising parental authority.

Where it's running

  • Ospedale Papa Giovanni XXIII USS Oncoematologia Pediatrica
    Bergamo, Italia, Italy
    Recruiting
  • Istituto Ortopedico Rizzoli Bologna Servizio di Assistenza Infermieristica, Tecnica e della Riabilitazione (SAITER)"
    Bologna, Italy
    Recruiting
  • IRCCS Eugenio Medea Associazione "La Nostra Famiglia"
    Bosisio Parini, Italy
    Recruiting
  • A.O.U. Policlinico Vittorio Emanuele U.O.C. Ematologia ed Oncologia Pediatrica con TMO
    Catania, Italy
    Recruiting
  • IRCCS Eugenio Medea Associazione "La Nostra Famiglia"
    Conegliano, Italy
    Recruiting
  • Azienda Ospedaliero-Universitaria "Anna Meyer" IRCCS - SOC Professioni tecnico sanitarie e della riabilitazione
    Florence, Italy
    Recruiting
Show 7 more locations
  • AOU Città della Salute e della Scienza di Torino
    Torino, Italy
    Recruiting
  • IRCCS Materno Infantile "Burlo Garofolo" Dipartimento Pediatrico S.C. Onco-ematologia Pediatrica SS Trapianto di Midollo
    Trieste, Italy
    Recruiting
  • AS dell'Alto Adige comprensorio di Bolzano Dipartimento di Pediatria
    Bolzano, Italy
    Not yet recruiting
  • IRCCS Eugenio Medea Associazione "La Nostra Famiglia"
    Brindisi, Italy
    Withdrawn
  • Fondazione IRCCS Istituto Nazionale Tumori S.C. Pediatrica Oncologica Milano
    Milan, Italy
    Active not recruiting
  • Azienda Ospedale Università di Modena Dipartimento Materno Infantile, Unità Operativa complessa di Pediatria ad indirizzo oncoematologico
    Modena, Italy
    Withdrawn
  • IRCCS Ospedale Pediatrico "Bambino Gesù" Dipartimento Ematologia Oncologia e medicina trasfusionale
    Roma, Italy
    Not yet recruiting

Study contacts

  • Principal investigator: Francesca Rossi Rossi, Master's degree — AOU Città della Salute e della Scienza di Torino - Ospedale Infantile Regina Margherita
  • Study coordinator: AIEOP Clinical trial office AIEOP Clinical trial office
  • Email: studiclinici@aieop.org
  • Phone: +390512144667

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.