Donation of pediatric tumor tissues and cells after death
Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
Ann & Robert H Lurie Children's Hospital of Chicago · NCT05120518
This study is trying to collect tumor tissues and cells from children who have passed away to help create better models for studying pediatric cancers and testing new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Sex | All |
| Sponsor | Ann & Robert H Lurie Children's Hospital of Chicago (other) |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT05120518 on ClinicalTrials.gov |
What this trial studies
This study aims to collect pediatric tumor tissues and cells from autopsies to create innovative patient-derived orthotopic xenograft (PDOX) mouse models and in vitro cell culture systems for pediatric cancers. The collected tissues will undergo thorough histopathological and molecular analysis, be cryopreserved for future studies, and be made available to other research organizations. This approach seeks to enhance understanding of pediatric cancers and improve preclinical drug testing methodologies.
Who should consider this trial
Good fit: Ideal candidates for this study are pediatric patients with cancer or non-cancer tumor types who have consented to post mortem tissue donation.
Not a fit: Patients who do not consent to post mortem tissue donation and autopsy will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better preclinical models for pediatric cancers, ultimately improving treatment options for affected children.
How similar studies have performed: While the approach of using post mortem tissues for research is established, the specific application to pediatric cancers through PDOX models is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology) * Signed consent for post mortem tissue donation and autopsy Exclusion Criteria: * Signed consent for post mortem tissue donation and autopsy not obtained
Where this trial is running
Chicago, Illinois
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States (RECRUITING)
Study contacts
- Principal investigator: Angela Waanders, MD — Ann & Robert H Lurie Children's Hospital of Chicago
- Study coordinator: Angela Waanders, MD
- Email: awaanders@luriechildrens.org
- Phone: 312-227-4090
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pediatric Cancer