Donation of pediatric tumor tissues and cells after death
Official title: Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
Run by Ann & Robert H Lurie Children's Hospital of Chicago · NCT05120518 · Data updated 2026-11-12
This study is trying to collect tumor tissues and cells from children who have passed away to help create better models for studying pediatric cancers and testing new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Ann & Robert H Lurie Children's Hospital of Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | August 14, 2019 |
| Main results expected | August 14, 2029 |
| Study ends | August 14, 2029 |
| Registry record updated | June 3, 2026 |
| Trial ID | NCT05120518 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are pediatric patients with cancer or non-cancer tumor types who have consented to post mortem tissue donation.
✕Probably not a fit
Patients who do not consent to post mortem tissue donation and autopsy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to collect pediatric tumor tissues and cells from autopsies to create innovative patient-derived orthotopic xenograft (PDOX) mouse models and in vitro cell culture systems for pediatric cancers. The collected tissues will undergo thorough histopathological and molecular analysis, be cryopreserved for future studies, and be made available to other research organizations. This approach seeks to enhance understanding of pediatric cancers and improve preclinical drug testing methodologies.
Why it matters
Potential benefit: If successful, this study could lead to better preclinical models for pediatric cancers, ultimately improving treatment options for affected children.
How similar studies have gone: While the approach of using post mortem tissues for research is established, the specific application to pediatric cancers through PDOX models is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology) * Signed consent for post mortem tissue donation and autopsy Exclusion Criteria: * Signed consent for post mortem tissue donation and autopsy not obtained
Where it's running
-
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States Recruiting
Study contacts
- Principal investigator: Angela Waanders, MD — Ann & Robert H Lurie Children's Hospital of Chicago
- Study coordinator: Angela Waanders, MD
- Email: awaanders@luriechildrens.org
- Phone: 312-227-4090
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
FaceSay: a computer program to help kids recognize facial expressions and improve social interactions
A computer-based FaceSay program is tested to see if it helps survivors of pediatric brain tumors who have social difficulties see facial expressions better and relate more comfortably with peers.
-
Access to Innovative Cancer Treatments for Children and Young People in Belgium
This observational study collects safety and effectiveness data on off‑label and compassionate cancer medicines used in kids and young adults up to age 25 in Belgium.
-
BCB-276 CAR T therapy for DIPG in children and young adults
This study tests BCB-276, a patient's own CAR T cells against DIPG, after standard radiation, to see if it is safe and can help extend survival.
-
CAYA cancer patients in LMICs: a forward-looking observation of care and outcomes
This study follows children, teens, and young adults with cancer in low- and middle-income countries to see how routine care affects treatment, access, and outcomes over time.
-
Virtual reality headsets to reduce anxiety and fear during intrathecal chemotherapy in children
This project will try virtual reality headsets with children aged 4–10 who are receiving intrathecal chemotherapy to see if they reduce anxiety, fear, and changes in vital signs.
-
Laser thermal therapy for young people with low-grade glioma
This research will test whether laser interstitial thermal therapy (LITT) can stop or slow recurrent or progressive low-grade gliomas in children, adolescents, and young adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.