Clinical trial Recruiting at 1 site Observational

Donation of pediatric tumor tissues and cells after death

Official title: Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells

Run by Ann & Robert H Lurie Children's Hospital of Chicago · NCT05120518 · Data updated 2026-11-12

This study is trying to collect tumor tissues and cells from children who have passed away to help create better models for studying pediatric cancers and testing new treatments.

More Pediatric Cancer trials

Quick facts

Study typeObservational
SexAll
Enrollment150 (estimated)
SponsorAnn & Robert H Lurie Children's Hospital of Chicago
Academic / other
Locations1 site (Chicago, Illinois)
StatusRecruiting
StartedAugust 14, 2019
Main results expectedAugust 14, 2029
Study endsAugust 14, 2029
Registry record updatedJune 3, 2026
Trial IDNCT05120518 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are pediatric patients with cancer or non-cancer tumor types who have consented to post mortem tissue donation.

Probably not a fit

Patients who do not consent to post mortem tissue donation and autopsy will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to collect pediatric tumor tissues and cells from autopsies to create innovative patient-derived orthotopic xenograft (PDOX) mouse models and in vitro cell culture systems for pediatric cancers. The collected tissues will undergo thorough histopathological and molecular analysis, be cryopreserved for future studies, and be made available to other research organizations. This approach seeks to enhance understanding of pediatric cancers and improve preclinical drug testing methodologies.

Why it matters

Potential benefit: If successful, this study could lead to better preclinical models for pediatric cancers, ultimately improving treatment options for affected children.

How similar studies have gone: While the approach of using post mortem tissues for research is established, the specific application to pediatric cancers through PDOX models is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology)
* Signed consent for post mortem tissue donation and autopsy

Exclusion Criteria:

* Signed consent for post mortem tissue donation and autopsy not obtained

Where it's running

  • Ann & Robert H. Lurie Children's Hospital of Chicago
    Chicago, Illinois, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.