Exploring the link between birth defects and childhood cancer
Official title: Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric Cancer
Funded at University of Tx Md Anderson Can Ctr · NIH-10931616 · Data updated 2026-11-12
This study is looking at how certain birth defects might raise the chances of kids getting cancer, and it aims to help families understand their health risks better by exploring the genetic links between these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $444,374 |
| NIH project number | 5R01CA284531-02 |
| Project ID | NIH-10931616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adolescents with congenital anomalies or those with a family history of congenital defects and cancer.
✕Less likely to help
Patients without congenital anomalies or those who are not at risk for pediatric cancers may not benefit from this research.
What this research studies
This research investigates how congenital anomalies, such as chromosomal abnormalities and non-chromosomal birth defects, may increase the risk of developing pediatric cancers. By analyzing data from birth defects and cancer registries, the study aims to identify specific genetic variations that contribute to these associations. Patients may benefit from a better understanding of their health risks and potential preventive measures based on their genetic background. The research combines epidemiological data with genomic assessments to uncover novel connections between congenital anomalies and cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and preventive strategies for children born with congenital anomalies.
How similar studies have gone: Previous studies have shown promising results in linking congenital anomalies to increased cancer risk, suggesting that this research builds on established findings.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Huff, Chad Daniel — University of Tx Md Anderson Can Ctr
- Study coordinator: Huff, Chad Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.