Condition

Parkinson Disease (PD) clinical trials and research

• 41Clinical trials
• 3NIH research projects
• 1New in 30 days
• 20Countries

Newest Parkinson Disease (PD) clinical trials

All recruiting trials (41)

• Parkinson’s Risk in Gaucher Disease Type 1

  This study tests how Parkinson’s risk relates to GBA1-related Gaucher disease in adults over 40, by collecting detailed clinical data and samples for future research.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT07886879

• Can the Ronnie Gardiner Method improve thinking and daily function in people with Parkinson’s

  In this 10-week program, adults with Parkinson’s disease will try the Ronnie Gardiner Method to see if it helps thinking, talking, movement, balance, and quality of life.

  Recruiting University Ghent · Ghent, Oost-Vlaanderen · NCT07863219

• Effects of excitatory and inhibitory LIFUS of GPi in Parkinson’s patients without DBS

  This study tests two deep-brain focused ultrasound patterns on people with Parkinson’s to see if they change task performance and tremor, compared with a sham stimulation.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07846007

• Capacitive-resistive radiofrequency therapy for people with Parkinson's disease

  This study tests four TECAR therapy protocols on the legs to see which best reduces muscle stiffness and improves walking in people with Parkinson's disease.

  Recruiting Universidad San Jorge · Zaragoza, Zaragoza · NCT07842926

• TRB-001 safety and immune response in early Parkinson's disease

  This early-phase study tests TRB-001 against placebo to see if it is safe and prompts an immune response in people with recently diagnosed Parkinson’s disease.

  Recruiting Phase 1 Tridem Bioscience FlexCo · Vienna · NCT07840027

• Bayesian optimization to tune DBS for better gait in Parkinson’s patients

  This study tests whether using Bayesian optimization can quickly find DBS settings that lengthen step length in people with Parkinson's who already have DBS in place.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT07835308

• rTMS-primed self-controlled practice for people with Parkinson’s disease

  This study tests whether priming motor training with rTMS and letting people with Parkinson’s control their practice improves motor learning and motivation.

  Recruiting National Taiwan University Hospital · Taipei, Zhongzheng Dist. · NCT07832695

• Benzhexol vs. Procyclidine for tremor in tremor-predominant Parkinson's

  This study tests whether benzhexol works as well as procyclidine to reduce tremor in adults with tremor-predominant Parkinson's disease who are taking levodopa.

  Recruiting King Edward Medical University · Lahore, Punjab Province · NCT07810296

• Real-world experiences of Inbrija for Parkinson's OFF episodes

  This study looks at how people with Parkinson’s who use Inbrija for OFF episodes feel and function in daily life.

  Recruiting Merz Pharmaceuticals GmbH · Altmünster and 1 other locations · NCT07797790

• Safinamide added to standard therapy for PD-related pain

  This Phase 3 trial tests whether safinamide, added to usual Parkinson’s medication, reduces PD-related pain more than placebo in adults with motor fluctuations and chronic pain.

  Recruiting Phase 3 Universita di Verona · Verona, Veneto · NCT07761936

• VG081821AC tablets for early to mid-stage Parkinson's disease

  This study tests VG081821AC to see if it can improve movement in adults with early to mid-stage Parkinson's disease, compared to placebo.

  Recruiting Phase 2/3 Zhejiang Vimgreen Pharmaceuticals, Ltd. · Beijing · NCT07725562

• Different Frequency Temporal Interference Stimulation for Parkinson’s Disease

  This trial tests whether using two different stimulation frequencies on opposite sides of the brain can improve movement and speech in people with Parkinson’s.

  Recruiting First Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT07721688

• L-theanine and the Mediterranean diet for sleep, gut health, and inflammation in Parkinson’s disease

  This study tests whether taking L-theanine and following a Mediterranean-style diet can help people with Parkinson’s disease by affecting sleep-related behavior, gut function, and inflammatory markers.

  Recruiting Medipol University · Istanbul · NCT07682532

• Bottle PEP breathing for expiratory strength in Parkinson’s patients

  A group of people with Parkinson’s disease will try a bottle-PEP breathing exercise at home for eight weeks to see if it improves expiratory muscle strength and related breathing parameters.

  Recruiting Marmara University · Istanbul, Maltepe · NCT07680725

• Blood-brain PET test with a new tracer for alpha-synuclein in PD, MSA, and healthy adults

  This early-phase study tests the safety of a new PET tracer, [11C]MODAG-005, in people with Parkinson’s disease, multiple system atrophy, and healthy adults to see if it can image alpha-synuclein in the brain.

  Recruiting Early Phase 1 MODAG GmbH · Tübingen, Baden-Wurttemberg · NCT07640542

• Probiotic Y7 cocktail to help with early Parkinson’s symptoms

  A 12-week randomized trial will test whether a probiotic Y7 cocktail helps people with early Parkinson’s disease by possibly improving motor, thinking, and everyday symptoms.

  Recruiting Taipei Medical University · Taipei · NCT07619560

• Robot-assisted gait training vs quadriceps NMES in Parkinson’s disease

  In people with Parkinson’s, this study tests whether robot-assisted walking training or quadriceps electrical stimulation added to a standard rehab program helps more with balance and walking.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Küçükçekmece, Istanbul · NCT07589296

• Bilateral putamen DopaCell transplant for Parkinson's disease

  This trial will test whether transplanting lab-grown dopamine-producing cells (DopaCells) into the putamen is safe and feasible for people with moderately severe Parkinson's disease.

  Recruiting at 3 sites Phase 1 Royan Institute · Shiraz and 2 other locations · NCT07572071

• Gut-brain in PD Consortium: understanding gut influences in Parkinson's and prodromal stages

  This study tests how the gut and brain communicate in people with Parkinson's, those without PD, and those at risk, to see if gut factors relate to disease onset and progression.

  Recruiting at 4 sites Duke University · Stanford, California and 6 other locations · NCT07567794

• Dual-task training to improve arm function in Parkinson's disease

  This trial tests whether doing dual-task training for eight weeks can improve upper-extremity function and muscle thickness in people with Parkinson's disease.

  Recruiting Ankara University · Ankara · NCT07536542

• Motor and cognitive exercise program for Parkinson's disease

  This project tests whether adding a 12-week supervised motor-and-cognitive exercise program to usual care improves walking and balance for people with Parkinson's disease who have had symptoms for at least 4 years.

  Recruiting University Hospital Bispebjerg and Frederiksberg · Copenhagen NV · NCT07465107

• Gentle brain stimulation plus Nordic walking for better walking and balance in Parkinson's

  This trial will test whether adding a gentle, non-invasive brain stimulation (tDCS) during supervised Nordic walking helps people with Parkinson's walk faster and steadier.

  Recruiting Universidade Metodista de Piracicaba · Belém, Pará · NCT07381907

• D-SPARK: D‑Serine to modify Parkinson's progression

  This trial will test whether taking D‑serine can slow Parkinson's progression in people diagnosed within five years.

  Recruiting at 3 sites Phase 2 Haukeland University Hospital · Arendal, Agder and 10 other locations · NCT07312110

• Ultrasound of abdominal breathing muscles in Parkinson's disease

  We will use ultrasound to measure abdominal breathing muscles to see if their thickness relates to disease severity and breathing strength in adults with Parkinson's disease.

  Recruiting Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Istanbul, BAHÇELİEVLER · NCT07308795

• Home and telerehabilitation exercise program for people with Parkinson's disease

  This program will try to see if people with Parkinson's who manage their own exercise using telerehabilitation get similar or better walking, function, quality of life, and exercise adherence compared with a supervised exercise program.

  Recruiting Marmara University · Maltepe, Istanbul · NCT07302386

• Remote ischemic conditioning to help sleep in Parkinson’s disease

  A small, randomized study will test if brief, controlled limb ischemia over 7 days can improve sleep and other non-motor symptoms in people with Parkinson’s and insomnia.

  Recruiting Jiangsu Province Nanjing Brain Hospital · Nanjing, Jiangsu · NCT07299240

• Cionic Neural Sleeve safety and ease of use for Parkinson's gait

  This test will see if the Cionic Neural Sleeve Multistim System is safe and easy to use for people with Parkinson's who have trouble walking.

  Recruiting at 2 sites Cionic, Inc. · Carlsbad, California and 1 other locations · NCT07284823

• DANU Smart Socks to measure walking and balance in Parkinson's

  This project will test whether DANU Smart Socks can measure walking and balance in people with Parkinson's and compare their results with healthy adults of similar age.

  Recruiting Northumbria University · Newcastle upon Tyne, Tyne and Wear and 1 other locations · NCT07281794

• Guided cycling, non-contact boxing, and physical therapy for movement, fitness, and quality of life in Parkinson's disease

  This study will test whether guided cycling, non-contact boxing, or standard physical therapy best improve movement, fitness, and quality of life for adults with Parkinson's disease.

  Recruiting at 2 sites University of Texas, El Paso · El Paso, Texas and 1 other locations · NCT07221266

• 18F-mFBG PET imaging of heart nerve uptake in Lewy body dementia and Parkinson disease.

  This study will test whether the PET tracer 18F-mFBG can measure loss of heart sympathetic nerve function in people with Lewy body dementia or Parkinson disease.

  Recruiting Phase 2 Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC) · Houston, Texas · NCT07176286

• Low-intensity focused ultrasound targeting a deep brain nucleus to reduce refractory hand tremor.

  This study will try low-intensity NaviFUS-ctbTUS focused ultrasound to see if it reduces hand tremor in adults with Parkinson's disease, essential tremor, or dystonic tremor that have not improved with medication.

  Recruiting National Taiwan University Hospital · Hsinchu, Hsinchu City · NCT07172295

• XS411 for early-onset Parkinson's disease

  This study will try a single injection of XS411 (iPSC-derived dopaminergic neural progenitor cells) to see if it is safe and helps people with early-onset Parkinson's disease whose motor symptoms are not controlled by medication.

  Recruiting Phase 1/2 XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. · Shanghai, Shanghai Municipality · NCT07166757

• PDR-001 delivered into the brain to remove harmful alpha-synuclein in early Parkinson's

  This trial will try PDR-001 (a peptide packaged in AAV9) injected into a brain target to remove toxic alpha-synuclein in people aged 40–65 with early Parkinson's disease.

  Recruiting Phase 1 Ruijin Hospital · Shanghai, Shanghai Municipality · NCT07157345

• Daily tailored amino acid supplement for people with Parkinson's disease

  This test will see if taking a daily tailored amino acid supplement for six months helps adults with Parkinson's disease improve nutrition, metabolism, body composition, and physical and mental function.

  Recruiting at 2 sites University of Connecticut · Farmington, Connecticut and 1 other locations · NCT07115563

• Hearing profiling in early Alzheimer's and Parkinson's

  This project will test detailed hearing tests to see if people with early Alzheimer's or Parkinson's have hidden hearing loss compared with healthy older adults.

  Recruiting at 4 sites Cilcare SAS · Montpellier and 3 other locations · NCT07083089

• Stepping program to improve walking and balance in Parkinson's disease

  This tests whether speed-dependent treadmill training, with or without mechanical or virtual-reality perturbations, can improve walking, balance, and daily-life mobility in people with mild-to-moderate Parkinson's disease who have gait problems.

  Recruiting The University of New South Wales · Randwick, New South Wales · NCT07057219

• Using AI to improve the levodopa challenge test for Parkinson's disease diagnosis

  This study is testing a new way to diagnose Parkinson's disease using artificial intelligence and video recordings to see if it can improve the accuracy of the levodopa challenge test.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT06949865

• Validation of α-synuclein biomarkers for Parkinson's disease

  This study is testing new ways to detect Parkinson's disease early by looking for specific proteins in the body, which could help patients get diagnosed more easily and quickly.

  Recruiting at 4 sites Casa di Cura IGEA · Thessaloniki and 3 other locations · NCT06941012

• Entacapone added to Madopar (levodopa/benserazide) for early Parkinson's disease: an observational comparison

  This project will see if adding entacapone to Madopar (levodopa/benserazide) helps people with early Parkinson's disease in China over 24 weeks.

  Recruiting Guangxi Medical University · Nanning, Guanxi · NCT06928519

• Robotic apparel to help prevent freezing of gait in Parkinson's disease

  This study is testing if soft robotic clothing can help people with Parkinson's disease walk better and reduce episodes of freezing while they move.

  Recruiting at 2 sites Harvard Medical School (HMS and HSDM) · Allston, Massachusetts and 1 other locations · NCT06602544

• Evaluating a new imaging biomarker for neuroinflammation in neurodegenerative diseases

  This study is testing a new imaging tool to see if it can help us understand brain inflammation in people with neurodegenerative diseases like ALS, Alzheimer’s, multiple sclerosis, and Parkinson’s, as well as in healthy volunteers.

  Recruiting at 3 sites Phase 1/2 Ashvattha Therapeutics, Inc. · San Francisco, California and 2 other locations · NCT05395624

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Regulatory DNA Variants in Parkinson’s Disease: How Noncoding Changes Shape Gene Activity

  A Johns Hopkins-led study will explore how noncoding genetic variants change gene activity and contribute to Parkinson’s disease risk, using brain cells and advanced chromatin mapping.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11380674

• How genetic regulatory changes influence Parkinson's disease risk

  This project will learn how small noncoding changes in DNA control genes and may increase Parkinson's disease risk for people with or at risk for PD.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11142505

• Investigating genetic variations that affect the risk of Parkinson's disease.

  This study is looking at how certain genetic differences in noncoding DNA might affect the risk and progression of Parkinson's disease, helping us understand how these variations influence gene activity and could lead to new insights for those living with the condition.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10977872

Related topics

Quick answers

How many Parkinson Disease (PD) clinical trials are recruiting right now?

41, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (9 trials), China (7 trials), Turkey (Türkiye) (6 trials), Taiwan (3 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 1/2: 2, Early Phase 1: 2, Phase 2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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