Benzhexol vs. Procyclidine for tremor in tremor-predominant Parkinson's

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, two-arm trial, adults with tremor-predominant Parkinson's disease on levodopa will receive either benzhexol or procyclidine in addition to their usual treatment. Tremor and other motor symptoms will be measured at baseline, 2 weeks, 3 months, and 6 months using the MDS-UPDRS-III tremor subset. Dosing starts with fixed ramp-ups and may be adjusted for tremor control and tolerability. The primary aim is to see if benzhexol provides tremor relief similar to procyclidine and to compare side effects between the two drugs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed Parkinson's disease according to the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's Disease, with predominant tremor at presentation.
* Hoehn and Yahr stage 1, 2, or 3.
* Any gender.
* Age 40 to 70 years.
* Receiving levodopa/carbidopa monotherapy for Parkinson's disease, with resting tremor present.

Exclusion Criteria:

* Cognitive or behavioral abnormalities.
* Lower urinary tract symptoms.
* Benign prostatic hyperplasia.
* Angle-closure glaucoma.
* Cardiac disease.

Where it's running

• Mayo Hospital Lahore
  Lahore, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Saad A Malik, MBBS
• Email: saadazhar@live.com
• Phone: +92-3005107713

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.