Robot-assisted gait training vs quadriceps NMES in Parkinson’s disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, randomized, assessor-blinded trial compares two adjunctive rehabilitation approaches for idiopathic Parkinson's disease. Participants receive a standard Parkinson's rehabilitation program, with one group also undergoing robot-assisted gait training and the other group receiving quadriceps NMES, five days a week for six weeks. Outcomes include balance, functional mobility, gait performance, and disease severity, measured at baseline, after treatment, and at week 14, plus ultrasound assessment of quadriceps muscle size. The goal is to determine which adjunctive therapy provides greater clinical and muscle-related benefits. Ultrasonography and blinded assessments are used to reduce bias in evaluating outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of Parkinson's disease according to established clinical criteria
* Age between 40 and 80 years
* Hoehn and Yahr stage II-III
* Ability to walk independently with or without assistive devices
* Stable medical treatment for at least 4 weeks prior to study enrollment
* Ability to understand and follow instructions
* Willingness to participate and provide written informed consent

Exclusion Criteria:

* Severe cognitive impairment or inability to follow instructions
* Hoehn and Yahr stage IV-V Parkinson's disease
* Severe musculoskeletal disorders affecting gait (e.g., advanced osteoarthritis, recent fracture)
* History of lower extremity surgery within the last 6 months
* Severe cardiovascular or respiratory disease limiting exercise participation
* Presence of other neurological disorders affecting mobility (e.g., stroke, multiple sclerosis)
* Contraindications to electrical stimulation (e.g., pacemaker, implanted electronic devices)
* Skin lesions or infections at electrode placement sites
* Participation in another structured rehabilitation program within the last 3 months

Where it's running

• Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
  Küçükçekmece, Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: dilek Ün Oğuzhanasiltürk, MD
• Email: dilekunoguzhan@gmail.com
• Phone: +90 5056367184

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.