Parkinson’s Risk in Gaucher Disease Type 1

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional study recruits adults over 40 with Gaucher disease type 1, GBA1 carriers, and controls to explore clinical and laboratory factors linked to current or future Parkinson’s risk. Neurological exams will be videotaped and audio-recorded to enable automated analysis of motor and speech features. Data and biospecimens will be de-identified and stored in a biobank for ongoing research into Gaucher disease and Parkinson’s disease. The project is led by Icahn School of Medicine at Mount Sinai with collaboration from the Michael J. Fox Foundation and Tel-Aviv Sourasky Medical Center. No interventional treatment is described; the focus is observational characterization and resource creation for future studies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects with a documentation of GBA1 phenotype
* Subjects older than 40 years old
* Either GD1 participants with or without PD
* GBA1 heterozygotes with or without PD
* Non-carrier controls without neurological disorder and no first-degree family relative with PD

Exclusion Criteria:

• Subjects with diminished mental capacity and unable to consent for themselves

Where it's running

• Icahn School of Medicine at Mount Sinai
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Drew Sinha, MD PhD — Icahn School of Medicine at Mount Sinai
• Study coordinator: Drew Sinha, MD PhD
• Email: drew.sinha@mssm.edu
• Phone: 646-761-7891

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.