Daily tailored amino acid supplement for people with Parkinson's disease
Effects of Targeted Amino Acid Supplementation for People With Parkinson's Disease on Amino Acid Profiles and Health Related Markers
This test will see if taking a daily tailored amino acid supplement for six months helps adults with Parkinson's disease improve nutrition, metabolism, body composition, and physical and mental function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | University of Connecticut Academic / other |
| Locations | 1 site (Storrs, Connecticut) |
| Trial ID | NCT07115563 on ClinicalTrials.gov |
What this trial studies
Adults aged 60–80 with idiopathic Parkinson's disease on stable dopamine-replacement therapy take either a targeted amino acid supplement or a placebo daily for six months. Researchers measure plasma amino acid availability, an antioxidant-related complex amino acid and an amino acid linked to oxidative stress, metabolic markers, body composition, physical function, and self-reported outcomes. Participants attend lab visits at baseline and three months for blood draws and functional testing, with monitoring for adherence and safety. The placebo-controlled comparison is designed to determine whether correcting PD-associated amino acid deficiencies leads to measurable clinical and biochemical improvements.
Who should consider this trial
Good fit: Ideal candidates are people aged 60–80 with idiopathic Parkinson's disease who have used dopamine-replacement medication for at least two years and have been on a stable dose for at least three months.
Not a fit: People with atypical Parkinsonism, significant cognitive impairment, unstable medical conditions, use of dopamine antagonists or blood thinners, prior gastric/bowel resection, deep brain stimulation, or contraindications to blood draw may not be eligible or likely to benefit.
Why it matters
Potential benefit: If successful, the supplement could improve nutritional status, lower oxidative-stress–related amino acids, and lead to better physical and mental functioning for people with Parkinson's disease.
How similar studies have performed: Nutritional and amino acid approaches have shown mixed but sometimes encouraging results in small studies, while a specifically tailored amino acid supplement for PD is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusionary Criteria: * Male and Females. * 60-80 Years. * Previous diagnosis of idiopathic Parkinson's Disease by patient report. * Use of dopamine replacement medication (e.g. levodopa) for at least 2 years. * On a stable dose of dopamine replacement medication for at least 3 months with no plans for change in the next two months. Exclusionary criteria * Apparent cognitive impairment as determined by phone screening (Telephone Interview for Cognitive Status \<29). * Diagnosis of Parkinsonism or atypical Parkinson's Disease. * Prescription of Dopamine antagonist. * Any unstable medical condition. * Any known bleeding disorder or current consumption of blood thinners. * Use of Deep Brain Stimulation. * Gastric or Bowel resection surgery. * Contraindications to blood draw.
Where this trial is running
Storrs, Connecticut
- University of Connecticut — Storrs, Connecticut, United States (Recruiting)
Study contacts
- Study coordinator: Carlos Rehbein, MS
- Email: carlos.rehbein@uconn.edu
- Phone: 860-486-1121
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.