Investigating genetic variations that affect the risk of Parkinson's disease.
Systematic investigation of disease-associated, regulatory variation; illuminating their prediction, molecular consequences and mechanisms contributing to risk of Parkinson disease (PD)
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10977872
This study is looking at how certain genetic differences in noncoding DNA might affect the risk and progression of Parkinson's disease, helping us understand how these variations influence gene activity and could lead to new insights for those living with the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10977872 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific genetic variations in noncoding DNA influence the risk and progression of Parkinson's disease (PD). By analyzing genomic data from various cellular contexts, the study aims to uncover the mechanisms through which these variations affect gene expression and contribute to disease susceptibility. The research employs advanced techniques like ATAC sequencing to identify open chromatin regions and transcription factors that play a role in PD. This comprehensive approach will help prioritize genetic variants for further functional analysis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Parkinson's disease, including those with a family history or genetic predispositions.
Not a fit: Patients with Parkinson's disease caused by known single-gene mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors contributing to Parkinson's disease, potentially paving the way for targeted therapies.
How similar studies have performed: Previous research has shown success in understanding genetic variations related to other diseases, suggesting that this approach could yield valuable insights for Parkinson's disease as well.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCCALLION, ANDREW S — JOHNS HOPKINS UNIVERSITY
- Study coordinator: MCCALLION, ANDREW S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.