Investigating genetic variations that affect the risk of Parkinson's disease.
Official title: Systematic investigation of disease-associated, regulatory variation; illuminating their prediction, molecular consequences and mechanisms contributing to risk of Parkinson disease (PD)
Funded at Johns Hopkins University · NIH-10977872 · Data updated 2026-11-12
This study is looking at how certain genetic differences in noncoding DNA might affect the risk and progression of Parkinson's disease, helping us understand how these variations influence gene activity and could lead to new insights for those living with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 22, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $635,430 |
| NIH project number | 1R01NS134805-01A1 |
| Project ID | NIH-10977872 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Parkinson's disease, including those with a family history or genetic predispositions.
✕Less likely to help
Patients with Parkinson's disease caused by known single-gene mutations may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic variations in noncoding DNA influence the risk and progression of Parkinson's disease (PD). By analyzing genomic data from various cellular contexts, the study aims to uncover the mechanisms through which these variations affect gene expression and contribute to disease susceptibility. The research employs advanced techniques like ATAC sequencing to identify open chromatin regions and transcription factors that play a role in PD. This comprehensive approach will help prioritize genetic variants for further functional analysis.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors contributing to Parkinson's disease, potentially paving the way for targeted therapies.
How similar studies have gone: Previous research has shown success in understanding genetic variations related to other diseases, suggesting that this approach could yield valuable insights for Parkinson's disease as well.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Mccallion, Andrew S — Johns Hopkins University
- Study coordinator: Mccallion, Andrew S
Related research
Other NIH-funded projects on the same topics.
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Regulatory DNA Variants in Parkinson’s Disease: How Noncoding Changes Shape Gene Activity
A Johns Hopkins-led study will explore how noncoding genetic variants change gene activity and contribute to Parkinson’s disease risk, using brain cells and advanced chromatin mapping.
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How genetic regulatory changes influence Parkinson's disease risk
This project will learn how small noncoding changes in DNA control genes and may increase Parkinson's disease risk for people with or at risk for PD.
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Protein aggregation and brain changes in Parkinson’s-related dementia
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Palmitoyltransferase and GBA1 function restoration in Parkinson’s and Lewy body dementia
A fast-moving study looks at whether tweaking a fat-attachment process on proteins can restore healthy enzyme function and slow the progression of Parkinson’s disease and Lewy body dementia.
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Dysarthria treatment in Parkinson’s patients: real-world use, barriers, and outcomes
A real-world study to understand how speech therapy for Parkinson’s-related dysarthria works for patients, families, and clinicians in everyday clinical settings.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.