Bottle PEP breathing for expiratory strength in Parkinson’s patients
Official title: The Effect of Bottle PEP Exercise on Expiratory Muscle Thickness, Strength, and Balance Parameters in Parkinson's Disease Patients
Run by Marmara University · NCT07680725 · Data updated 2026-11-12
A group of people with Parkinson’s disease will try a bottle-PEP breathing exercise at home for eight weeks to see if it improves expiratory muscle strength and related breathing parameters.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 42 (estimated) |
| Sponsor | Marmara University Academic / other |
| Locations | 1 site (Istanbul, Maltepe) |
| Status | Recruiting |
| Started | October 1, 2025 |
| Main results expected | October 1, 2026 |
| Study ends | November 1, 2026 |
| Registry record updated | July 2, 2026 |
| Trial ID | NCT07680725 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18-75 with a confirmed Parkinson’s diagnosis who are ambulatory and enrolled at Marmara University.
✕Probably not a fit
Patients with cognitive or hearing impairments preventing exercise, or with severe comorbidities that limit participation, may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study compares two approaches added to standard neurological rehabilitation for Parkinson’s disease: (1) expiratory-strengthening exercises and (2) bottle-PEP breathing against a water-filled bottle device. Participants are assigned to groups using a computer-assisted list and complete an eight-week home program with five days of training per week. Outcomes focus on expiratory muscle thickness and strength, balance, and related respiratory measures. The study is conducted at Marmara University in Istanbul and includes adults with confirmed PD who are ambulatory. Both groups receive routine PD rehabilitation; the comparison aims to see if bottle-PEP provides additional benefit over standard expiratory exercises.
Why it matters
Potential benefit: If successful, the approach could provide a simple, low-cost method to improve breathing muscle strength and potentially reduce respiratory-related morbidity in PD.
How similar studies have gone: Previous studies show inspiratory or expiratory training can improve respiratory parameters in PD, but dedicated bottle-PEP–style expiratory strengthening remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a confirmed Parkinson's diagnosis who are being monitored * Those aged 18-75 * Patients who are ambulatory Exclusion Criteria: * Patients with acquired primary motor neuron disease (ischemic/hemorrhagic stroke, intracranial mass) and additional neurological diagnoses * Patients with hearing and cognitive impairments that prevent them from understanding or performing the exercise program * Presence of concomitant acute or chronic lung disease * History of thoracic or abdominal surgery * Severe heart disease * Active cancer * Mini-Mental State Examination (MMSE) score ≤ 24 * Active smoking
Where it's running
-
Marmara University Medical Faculty
Istanbul, Maltepe, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Ozge Kenis Coskun, Professor — Marmara University
- Study coordinator: Sevim Sensoy, Resident Doctor
- Email: sensoysevim@gmail.com
- Phone: 905436990767
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.