Motor and cognitive exercise program for Parkinson's disease
Motor and Cognitive Exercise in Parkinson's Disease. A Feasibility Randomized Clinical Trial
This project tests whether adding a 12-week supervised motor-and-cognitive exercise program to usual care improves walking and balance for people with Parkinson's disease who have had symptoms for at least 4 years.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital Bispebjerg and Frederiksberg Academic / other |
| Locations | 1 site (Copenhagen NV) |
| Trial ID | NCT07465107 on ClinicalTrials.gov |
What this trial studies
In a randomized 1:1 feasibility trial, 48 people with Parkinson's disease and symptom duration of four or more years will be assigned to usual care or to a 12-week supervised exercise program plus usual care. The intervention includes treadmill gait and dual-task motor-cognitive training, progressive gait and balance exercises, and progressive lower-body resistance training delivered three times per week for one hour by a physiotherapist or exercise physiologist. Outcomes will be measured at baseline, 12 weeks, and at 6- and 12-month follow-up to capture short- and longer-term effects. The protocol was developed with the Copenhagen Trial Unit and detailed training protocols will be shared to support reproducibility.
Who should consider this trial
Good fit: Adults (≥18 years) with Parkinson's disease by MDS criteria, symptom duration of at least 4 years, who can walk independently and can provide informed consent are ideal candidates.
Not a fit: People with Parkinson's disease dementia, those unable to walk independently, or with unstable medical issues are unlikely to benefit or may be ineligible.
Why it matters
Potential benefit: If successful, the program could improve gait and balance, help reduce fall risk, and preserve mobility for people with moderate-to-advanced Parkinson's disease.
How similar studies have performed: Previous exercise and dual-task training studies in Parkinson's disease have shown promising improvements in gait and balance, so this builds on encouraging but not definitive evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of PD according to MDS-PD criteria * Aged ≥ 18 years * Informed consent * PD symptoms ≥ 4 years * Independent gait Exclusion Criteria: * Diagnosis of PD Dementia according to the MDS-PD Dementia criteria
Where this trial is running
Copenhagen NV
- Department of Neurology, Bispebjerg and Frederiksberg Hospital — Copenhagen NV, Denmark (Recruiting)
Study contacts
- Study coordinator: Annemette Løkkegaard, MD, PhD
- Email: annemette.loekkegaard@regionh.dk
- Phone: +45 38 63 52 48
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.