Nervous system blocks to ease pain after lung cancer surgery
Official title: Postoperative Analgesic Effects of Ultrasound-guided Retro-superior Costotransverse Ligament Space Block After Video-assisted Thoracoscopic Surgery: a Prospective Randomized Controlled Trial
Run by Nanjing First Hospital, Nanjing Medical University · NCT07745881 · Data updated 2026-11-12
This trial tests whether retro-SCTLB or TPVB can reduce the need for opioid pain medicines after thoracoscopic radical lung cancer surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 130 (estimated) |
| Sponsor | Nanjing First Hospital, Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Status | Recruiting |
| Started | August 5, 2026 |
| Main results expected | May 20, 2028 |
| Study ends | May 30, 2028 |
| Registry record updated | August 6, 2026 |
| Trial ID | NCT07745881 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 18–80 planning thoracoscopic radical lung cancer surgery, with BMI 18–30 and ASA I–III, who consent to participate.
✕Probably not a fit
Patients with allergies to local anesthetics, opioid abuse history, active infection at the puncture site, peripheral neuropathy, or coagulation dysfunction may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this randomized study, adults aged 18–80 undergoing thoracoscopic radical resection of lung cancer are assigned to receive either ultrasound-guided retro-SCTLB or ultrasound-guided TPVB before anesthesia. The goal is to compare postoperative opioid use between the two blocks as a measure of analgesic effect. Procedures are performed 15 minutes before general anesthesia, with ultrasound guidance to place the block. Outcomes focus on analgesic requirements and safety in a single-center setting. The study involves 130 patients split evenly between the two groups.
Why it matters
Potential benefit: If successful, patients may experience better pain relief with less opioid use after surgery.
How similar studies have gone: Previous work suggests nerve blocks can reduce postoperative pain, but direct comparison of retro-SCTLB versus TPVB for this surgery is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients scheduled for thoracoscopic radical lung cancer surgery under general anesthesia; * aged 18-80 years; * BMI 18-30 kg/m²; * ASA classification I-III; Exclusion Criteria: * Allergy to the study drug or local anesthetic; * History of opioid abuse; * Pre-existing skin infection at the puncture site of ITPN or TPVB; * Peripheral infectious neuropathy; * Dysfunction of blood coagulation;
Where it's running
-
Nanjing First Hospital
Nanjing, Jiangsu, China Recruiting
Study contacts
- Study coordinator: Tao Shan
- Email: shantao2021@163.com
- Phone: 18852095135
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.