Non-Addictive Nose Spray Nerve Block for Quick Migraine Relief
Official title: Development of a Non-Addictive Intranasal Nerve Block to Provide Rapid Acute Treatment for Headache Disorders
Funded at Olfax, LLC · NIH-11405684 · Data updated 2026-11-12
A new nasal nerve-blocking treatment being tested to relieve migraine attacks quickly without addictive drugs.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Olfax, LLC NIH-funded |
| Lab location | 1 site (Asheville, United States) |
| Project start | September 3, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,446,740 |
| NIH project number | 1R44NS149824-01 |
| Project ID | NIH-11405684 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older who experience migraine episodes and are seeking rapid, non-addictive treatment options.
✕Less likely to help
Individuals without migraine or those whose attacks do not respond to nasal nerve-block approaches may not benefit.
What this research studies
This project aims to develop a rapid, non-addictive nasal nerve-block formulation to treat acute migraine symptoms. It will explore how delivering a targeted nerve block through the nose can stop migraine pain fast, potentially reducing the need for stronger medications. Researchers plan to test the approach in adults with migraine and monitor safety, pain relief, and any side effects. If successful, the method could offer a convenient, early intervention that patients can use at home or in urgent care settings.
Why it matters
Potential benefit: If successful, patients could experience faster relief from migraine attacks with fewer drug side effects and reduced reliance on opioids or other strong medications.
How similar studies have gone: Previous research supports rapid relief methods targeting trigeminovascular pathways, but this nasal-block approach is a newer, potentially more direct strategy for acute migraine.
Where this research is happening
-
Olfax, LLC
Asheville, United States Active
Researchers
- Principal investigator: Cook, Jason T — Olfax, LLC
- Study coordinator: Cook, Jason T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.