Minimal Effective Volume for double-injection costoclavicular block
Official title: Minimum Effective Volume of Lidocaine for Double-Injection Ultrasound-Guided Costoclavicular Block
Run by McGill University Health Centre/Research Institute of the McGill University Health Centre · NCT07374952 · Data updated 2026-11-12
This study tests the smallest amount of lidocaine that still provides a successful double-injection costoclavicular nerve block in adults having upper-extremity surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre Academic / other |
| Locations | 1 site (Montreal, Quebec) |
| Status | Recruiting |
| Started | June 16, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | July 7, 2026 |
| Trial ID | NCT07374952 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–70 years old with ASA physical status 1–3 undergoing upper-extremity surgery, without contraindications to lidocaine.
✕Probably not a fit
Patients not achieving a successful block at the tested doses may not benefit from the procedure under study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will use a biased coin design to find the dose that achieves a successful block with two injections in the costoclavicular area under ultrasound guidance. The volume starts at 30 mL and is adjusted in small increments depending on whether the previous patient had a successful block, aiming to estimate the ED90. Two thirds of the anesthetic is deposited deep between the medial cord and axillary artery, and one third is placed superficially next to the lateral cord. The study enrolls up to 60 adults aged 18–70 with ASA 1–3 undergoing elbow or below-elbow surgery at Montreal General Hospital. Outcomes include block success at each dose and derived ED90 with bootstrap CIs.
Why it matters
Potential benefit: If successful, this approach could reduce anesthetic exposure while maintaining block efficacy.
How similar studies have gone: Prior work suggested a two-injection method is optimal for costoclavicular blocks, supporting further dose-finding work like this study.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 70 years * American Society of Anesthesiologists classification 1-3 * Body mass index between 20 and 30 Exclusion Criteria: * Adults who are unable to give their own consent * Pre-existing neuropathy (assessed by history and physical examination) * Coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets≤ 100, International Normalized Ratio≥ 1.4 or partial prothrombin time ≥ 50) * Renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine≥ 100) * Hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases≥ 100) * Allergy to LA * Pregnancy * Prior surgery in the infraclavicular region * Chronic pain syndromes requiring opioid intake at home
Where it's running
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Montreal General Hospital
Montreal, Quebec, Canada Recruiting
Study contacts
- Study coordinator: Julián Aliste, M.D.
- Email: julian.aliste@mcgill.ca
- Phone: +15149341934-43795
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.