Nerve block comparison for CT-guided lung nodule localization: retro‑SCTLB versus TPVB
Official title: Comparison of Local Anaesthetic Spread Between the Retro-superior Costotransverse Ligament Space Block and Thoracic Paravertebral Block: A Three-dimensional CT Reconstruction Imaging Study
Run by Nanjing First Hospital, Nanjing Medical University · NCT07153263 · Data updated 2026-11-12
This trial will try two ultrasound-guided nerve blocks—retro‑SCTLB and thoracic paravertebral block (TPVB)—to see which gives wider local anesthetic spread and sensory numbness for adults having CT‑guided lung nodule localization.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Nanjing First Hospital, Nanjing Medical University Academic / other |
| Locations | 2 sites (Nanjing, Jiangsu and 1 other locations) |
| Status | Recruiting |
| Started | September 12, 2025 |
| Main results expected | September 15, 2026 |
| Study ends | September 30, 2026 |
| Registry record updated | August 28, 2026 |
| Trial ID | NCT07153263 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 with BMI 18–30 kg/m², ASA physical status I–III, who are scheduled for CT-guided lung nodule localization under local anesthesia are the intended candidates.
✕Probably not a fit
Patients with allergy to the study local anesthetic, coagulation dysfunction, skin infection at the puncture site, peripheral infectious neuropathy, a history of opioid abuse, or those outside the age/BMI limits may not benefit and are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Forty adults undergoing CT-guided lung nodule localization under local anesthesia will be randomized 1:1 to receive either ultrasound-guided retro‑SCTLB or ultrasound-guided TPVB before the localization procedure. Group allocation is concealed using sealed opaque envelopes prepared by an uninvolved nurse to maintain objectivity. The study will compare the radiographic diffusion range of the local anesthetic and the sensory block range measured after the block. Standard inclusion criteria include age 18–80, BMI 18–30 kg/m², and ASA I–III, while patients with local infection, coagulation dysfunction, opioid abuse history, or allergy to local anesthetics are excluded.
Why it matters
Potential benefit: If successful, the results could identify the nerve block technique that provides more reliable numbness and potentially safer or more effective anesthesia during CT-guided lung nodule localization.
How similar studies have gone: Thoracic paravertebral block (TPVB) is a well-established technique with supportive evidence, while retro‑SCTLB is a newer approach with limited direct comparative data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients scheduled for CT-guided lung nodule localization under local anesthesia will be selected 1. aged 18-80 years 2. BMI 18-30 kg/m² 3. ASA classification I-III Exclusion Criteria: 1. Allergy to the study drug or local anesthetic; 2. History of opioid abuse; 3. Pre-existing skin infection at the puncture site of ITPN or TPVB; 4. Peripheral infectious neuropathy; 5. Dysfunction of blood coagulation
Where it's running
-
Tao Shan
Nanjing, Jiangsu, China Recruiting -
Nanjing First Hospital
Nanjing, China Recruiting
Study contacts
- Study coordinator: Tao Shan
- Email: shantao2021@163.com
- Phone: +8618852095135
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.