Clinical trial Recruiting at 2 sites Interventional Ages 18 to 80

Nerve block comparison for CT-guided lung nodule localization: retro‑SCTLB versus TPVB

Official title: Comparison of Local Anaesthetic Spread Between the Retro-superior Costotransverse Ligament Space Block and Thoracic Paravertebral Block: A Three-dimensional CT Reconstruction Imaging Study

Run by Nanjing First Hospital, Nanjing Medical University · NCT07153263 · Data updated 2026-11-12

This trial will try two ultrasound-guided nerve blocks—retro‑SCTLB and thoracic paravertebral block (TPVB)—to see which gives wider local anesthetic spread and sensory numbness for adults having CT‑guided lung nodule localization.

Quick facts

Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment50 (estimated)
SponsorNanjing First Hospital, Nanjing Medical University
Academic / other
Locations2 sites (Nanjing, Jiangsu and 1 other locations)
StatusRecruiting
StartedSeptember 12, 2025
Main results expectedSeptember 15, 2026
Study endsSeptember 30, 2026
Registry record updatedAugust 28, 2026
Trial IDNCT07153263 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–80 with BMI 18–30 kg/m², ASA physical status I–III, who are scheduled for CT-guided lung nodule localization under local anesthesia are the intended candidates.

Probably not a fit

Patients with allergy to the study local anesthetic, coagulation dysfunction, skin infection at the puncture site, peripheral infectious neuropathy, a history of opioid abuse, or those outside the age/BMI limits may not benefit and are excluded.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Forty adults undergoing CT-guided lung nodule localization under local anesthesia will be randomized 1:1 to receive either ultrasound-guided retro‑SCTLB or ultrasound-guided TPVB before the localization procedure. Group allocation is concealed using sealed opaque envelopes prepared by an uninvolved nurse to maintain objectivity. The study will compare the radiographic diffusion range of the local anesthetic and the sensory block range measured after the block. Standard inclusion criteria include age 18–80, BMI 18–30 kg/m², and ASA I–III, while patients with local infection, coagulation dysfunction, opioid abuse history, or allergy to local anesthetics are excluded.

Why it matters

Potential benefit: If successful, the results could identify the nerve block technique that provides more reliable numbness and potentially safer or more effective anesthesia during CT-guided lung nodule localization.

How similar studies have gone: Thoracic paravertebral block (TPVB) is a well-established technique with supportive evidence, while retro‑SCTLB is a newer approach with limited direct comparative data.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Patients scheduled for CT-guided lung nodule localization under local anesthesia will be selected

1. aged 18-80 years
2. BMI 18-30 kg/m²
3. ASA classification I-III

Exclusion Criteria:

1. Allergy to the study drug or local anesthetic;
2. History of opioid abuse;
3. Pre-existing skin infection at the puncture site of ITPN or TPVB;
4. Peripheral infectious neuropathy;
5. Dysfunction of blood coagulation

Where it's running

  • Tao Shan
    Nanjing, Jiangsu, China
    Recruiting
  • Nanjing First Hospital
    Nanjing, China
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.