Condition

Meningitis clinical trials and research

• 13Clinical trials
• 43NIH research projects
• 9Countries

Newest Meningitis clinical trials

All recruiting trials (13)

• Group-based Emotional Awareness and Expression Therapy to Support Recovery After Acquired Brain Injury

  A group therapy program based on EAET is tested to see if it helps adults 18-65 with acquired brain injury improve emotional well-being and daily functioning.

  Recruiting Uppsala University · Uppsala · NCT07852936

• Predicting Meningitis/Encephalitis Pathogens with a Rapid BioFire Panel in Adults

  This study tests whether using the BioFire FilmArray Meningitis/Encephalitis panel in adults with suspected CNS infection can quickly identify the cause and reduce hospital stay and antibiotic use.

  Recruiting Federal University of Health Science of Porto Alegre · Porto Alegre, Rio Grande do Sul · NCT07432113

• Community spread of multiple infectious diseases in Cambodia from a One Health perspective

  This project will test how common and connected dengue, chikungunya, Zika, Japanese encephalitis, and West Nile infections are among people, animals, and the environment across Cambodia.

  Recruiting Institut Pasteur du Cambodge · Phnom Penh, Phnom Penh · NCT07358910

• Optic nerve ultrasound to detect brain inflammation and raised intracranial pressure

  This project will test whether bedside optic nerve ultrasound can quickly detect brain inflammation and high intracranial pressure in adults with suspected meningitis, encephalitis, stroke, or brain tumors.

  Recruiting at 2 sites Spitalul Clinic de Boli Infecțioase și tropicale "Dr. Victor Babeș" · Bucharest, Bucharest and 1 other locations · NCT07332234

• BPaLMZ for TB Meningitis: a two-stage trial comparing an experimental regimen to standard therapy

  This phase 2 trial tests whether the BPaLMZ combination can be better than standard TB meningitis treatment in adults living with HIV who have TB meningitis.

  Recruiting at 2 sites Phase 2 University of Minnesota · Kampala and 1 other locations · NCT07227779

• Tracking acute treatment and long-term outcomes in children with meningitis

  This registry will collect care and outcome information to see how current treatments affect short- and long-term outcomes in children under 18 with suspected meningitis in Brazil.

  Recruiting Hospital Israelita Albert Einstein · São Paulo, São Paulo · NCT07062445

• Acute treatment and long-term follow-up of adults with infectious meningitis

  This project will collect information to see how adults hospitalized with different types of infectious meningitis are treated and how they do during and after hospitalization in Brazil.

  Recruiting at 5 sites Hospital Israelita Albert Einstein · Fortaleza, Ceará and 5 other locations · NCT07027475

• Using ultrasound to improve lumbar puncture success in children

  This study is testing whether using ultrasound can help doctors successfully perform lumbar punctures in children under 18 years old.

  Recruiting Medical University of Warsaw · Warsaw · NCT06584864

• Investigating meningitis causes and prevention in rural Uganda

  This study is trying to understand the causes and prevention of meningitis in rural Uganda by looking at patients with symptoms and screening HIV-positive individuals to improve care and vaccination efforts.

  Recruiting University of Rochester · Lira · NCT05496673

• Improving emotions and behaviors after brain injury

  This study is testing whether Dialectical Behavior Therapy can help people with brain injuries improve their emotions and behaviors, and support their families in the process.

  Recruiting University Hospital, Strasbourg, France · Illkirch-Graffenstaden · NCT05393492

• National survey on bacterial meningitis in children

  This study is trying to learn more about bacterial meningitis in children by looking at which bacteria are causing it and how things have changed since the introduction of vaccines.

  Recruiting Association Clinique Thérapeutique Infantile du val de Marne · Créteil · NCT04664569

• Monitoring central nervous system infections in Denmark

  This study is looking at how community-acquired central nervous system infections, like meningitis and encephalitis, affect adults in Denmark to better understand their symptoms, treatments, and recovery outcomes.

  Recruiting at 8 sites Aalborg University Hospital · Aalborg and 7 other locations · NCT03418441

• Pneumococcal infection surveillance in Lebanon

  This study is trying to find out which types of bacteria cause serious infections like pneumonia in Lebanon and how well current vaccines and antibiotics work against them.

  Recruiting American University of Beirut Medical Center · Beirut · NCT00901602

NIH-funded research (newest 40 of 43)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Personalized Immunomodulatory Therapy for HIV-related Cryptococcal Meningitis

  A patient-focused study investigates a personalized treatment approach to improve outcomes for people with HIV who develop cryptococcal meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11615077

• Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis

  A study in Uganda aims to use faster, better tests and a new antifungal to help people with HIV who develop meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11539368

• TB meningitis diagnostic test compare and cost study in sub-Saharan Africa

  Researchers are testing a new CSF urine-based test (SILVAMP TB LAM) to improve diagnosis of TB meningitis in people with HIV, to help speed treatment and reduce death in Sub-Saharan Africa.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11536232

• Minimally Invasive Sampling to Improve HIV-Associated M meningitis Diagnosis in Africa

  A research study is testing easier, less invasive ways to diagnose meningitis in people living with HIV, with a focus on making diagnosis faster and more accurate in Africa and the US.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11516017

• Understanding brain injury in kids with tuberculous meningitis (iThemba)

  A study in children with TB meningitis in South Africa will look at how inflammation and blood-clotting factors relate to brain injury and infarcts.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11474075

• Serological clues to survival in HIV-related cryptococcal meningitis

  This grant looks for antibody signals in the blood that could predict who survives cryptococcal meningitis in people with HIV.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11432319

• Blood-brain barrier problems during bacterial meningitis

  Researchers are studying why the brain’s protective barrier fails during bacterial meningitis and how that leads to brain injury, with a focus on how bacteria invade brain cells and disrupt protective transporters.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11431371

• Improving TB meningitis diagnosis and treatment response with metagenomics and host genes in a multinational trial

  A large study will use advanced genetic analysis of pathogens and the patient’s own immune signals to better diagnose tuberculous meningitis and track how people respond to treatment.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11406305

• Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-Related Meningitis

  This project tests faster, better ways to diagnose HIV-related meningitis and improve brain health in adults in Africa.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11406140

• New TB meningitis test methods and cost check in Sub-Saharan Africa

  A study to see how well the SILVAMP TB LAM test works on spinal fluid for diagnosing TB meningitis and whether it is cost-effective, focusing on people with HIV in Sub-Saharan Africa.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11400971

• Faster, more accurate tests for tuberculosis in the brain (TB meningitis)

  This project is testing a rapid LAM antigen test called FujiLAM on spinal fluid to help doctors find TB meningitis, especially in people with HIV.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11397918

• Minimally invasive tissue testing for meningitis in people with HIV in Zambia

  Using small tissue and spinal fluid samples, doctors will look for infections and markers that explain and help diagnose meningitis in people living with HIV in Zambia.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11397442

• Higher-dose rifampin to help adults with tuberculous meningitis by measuring drug levels

  Adults with tuberculous meningitis receive higher-dose rifampin while researchers measure drug levels in blood and spinal fluid to link dosing with survival and brain injury, including people living with HIV.

  NIH research Stichting Radboud Universitair Medisch Centrum I.o. · Nijmegen, Netherlands · NIH-11394772

• Understanding brain injury in children with tuberculous meningitis

  This project studies how TB meningitis causes brain injury in children and how this disease progresses over time.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11394041

• Better diagnosis and brain health for people with HIV meningitis

  This project tries faster tests and a new oral antifungal to help adults with HIV who develop meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11383982

• Using genomics to improve care for cryptococcal meningitis in people with HIV

  This project builds lab and training capacity to use genomic and immune testing to help adults with HIV who get cryptococcal meningitis.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11381310

• Building genomic expertise to combat cryptococcal meningitis

  This program helps local labs and scientists in Africa use genome and immune testing to improve diagnosis and treatment for adults with cryptococcal meningitis.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11381293

• Brain blood flow and clotting problems in children with tuberculous meningitis

  This project looks at why some children with tuberculous meningitis get brain infarcts by using scans and tests of blood and spinal fluid.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11376814

• Targeting a special fungal cell type to treat fungal meningitis

  A new NIH-funded project aims to block and treat fungal meningitis caused by Cryptococcus in people with AIDS, focusing on a unique cell form that helps the fungus spread to the brain.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11371308

• Illuminating environmental sensing in fungal meningitis pathogen Cryptococcus neoformans

  A study in a human fungal pathogen aims to map how genes work together and respond to drugs to find new ways to treat fungal meningitis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11348189

• Strategy for personalized immune therapy in HIV-related cryptococcal meningitis

  This grant tests a personalized immunomodulatory approach to help people with HIV and cryptococcal meningitis improve outcomes.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11329210

• Understanding long-term brain changes after a serious infection in people with HIV

  This research looks at the lasting brain and thinking problems that can happen to people with HIV after they recover from a severe brain infection called cryptococcal meningitis.

  NIH research Infectious Diseases Institute · Kampala, Uganda · NIH-11172596

• IV ceftriaxone versus oral doxycycline for Lyme meningitis in children

  This project compares IV ceftriaxone and oral doxycycline as treatments for children with Lyme meningitis to find which leads to good recovery with fewer complications.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11163246

• Immune responses in tuberculous meningitis among adults with HIV

  This work looks at immune signals in spinal fluid from adults with HIV and suspected tuberculous meningitis to find hidden infections and point to possible immune-based treatments.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11146547

• Faster diagnosis and better brain health after HIV-associated meningitis

  This project tests faster bedside and lab tests plus a new oral antifungal to help adults with HIV who develop meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11141078

• Why children with tuberculous meningitis develop brain ischemia

  Researchers will collect brain scans, blood, and spinal fluid from children with tuberculous meningitis to learn what triggers strokes and long-term disability.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11136861

• How a fungal pathogen affects immune cell behavior

  This study is looking at how a fungus called Cryptococcus neoformans tricks our immune cells to help it survive and cause meningitis, with the goal of finding new ways to treat infections for people who are affected.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11086631

• Understanding how a fungal pathogen senses its environment

  This study is looking at how certain genes in a fungus that causes meningitis work, so we can find better ways to treat the infection and help patients feel better.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11029995

• Developing new tests for diagnosing TB meningitis and histoplasmosis

  This study is working on new and better tests to quickly and accurately diagnose TB meningitis and histoplasmosis, especially in places that don't have a lot of resources, to help save lives and reduce the high death rates from these serious infections.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11019367

• Using genomics and immune science to fight cryptococcal meningitis in people with HIV

  This project uses genetic and immune testing and builds local laboratory capacity to find better treatments for cryptococcal meningitis in adults with advanced HIV in Africa.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-10999571

• Understanding long-term brain effects after cryptococcal meningitis in HIV patients

  This study is looking at how cryptococcal meningitis affects the brain over time in people with HIV, to see if they have lasting memory or thinking problems and what might cause them, so we can find better ways to help improve their brain health.

  NIH research Infectious Diseases Institute · Kampala, Uganda · NIH-10999483

• Improving diagnosis and treatment for meningitis in HIV/AIDS patients

  This study is all about finding better ways to diagnose and treat serious brain infections like cryptococcal and TB meningitis that can affect people with weakened immune systems, especially those living with HIV/AIDS, so we can help improve their health and care.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10924701

• Comparing two antibiotics for treating Lyme meningitis in children

  This study is looking at how well two different antibiotics work for treating Lyme meningitis in kids, to see which one helps them recover better and feel good in the long run, and it involves children from 20 places in the U.S. where Lyme disease is common.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10911066

• Understanding brain blood flow changes in HIV-related TB meningitis and stroke.

  This study is looking at how tuberculous meningitis affects blood flow in the brain and the risk of stroke for people living with HIV, using special imaging techniques to better understand these changes and their impact on long-term brain health.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10892287

• Investigating immune responses in TB meningitis among HIV-infected individuals

  This study is looking at how the immune system responds in people with tuberculous meningitis who also have HIV, to find out what helps them do better or worse, with the hope of improving diagnosis and treatment options for patients in Uganda.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10888216

• Improving survival in patients with cryptococcal meningitis and altered mental status

  This study is looking at how cryptococcal meningitis affects the brain in people with HIV/AIDS, hoping to find out what changes happen that might make things worse, so we can improve treatments and help patients live better.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10873789

• Improving understanding and outcomes in Tuberculous meningitis

  This study is looking at why some people with tuberculous meningitis, especially those with HIV, have a harder time recovering, and it aims to find better ways to treat this serious condition by exploring how the immune system works and how well medications reach the brain.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-10808957

• Investigating treatments for Tuberculous Meningitis using animal models

  This study is looking at how to make treatments better for tuberculous meningitis, especially for young kids and people with HIV, by using rabbits to see how well different medicines can reach the brain and reduce inflammation.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10805504

• How bacterial meningitis affects blood vessels in the brain

  This study is looking at how bacterial meningitis affects the protective barrier around the brain, using special human cell models to see how bacteria can break through and cause problems, with the hope of finding new ways to help people who are dealing with this serious illness.

  NIH research University of Alabama in Tuscaloosa · Tuscaloosa, United States · NIH-10795568

• Understanding the impact of childhood tuberculous meningitis on health outcomes.

  This study is looking at how childhood tuberculous meningitis affects kids' health, especially in countries with fewer resources, to help create better care and support for those who are sick.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-10763370

Related topics

Quick answers

How many Meningitis clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in Brazil (3 trials), France (2 trials), Uganda (2 trials), Romania (1 trial), Denmark (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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