Understanding brain blood flow changes in HIV-related TB meningitis and stroke.
Cerebral Hemodynamics and Stroke in HIV-associated TB Meningitis.
This study is looking at how tuberculous meningitis affects blood flow in the brain and the risk of stroke for people living with HIV, using special imaging techniques to better understand these changes and their impact on long-term brain health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10892287 on NIH RePORTER |
What this research studies
This research investigates how tuberculous meningitis (TBM) affects brain blood flow and the risk of stroke in individuals living with HIV. By using advanced imaging techniques like transcranial Doppler and brain scans, the study aims to identify changes in cerebral blood vessels and blood flow patterns. The researchers will explore how these changes relate to the risk of stroke and long-term neurological outcomes in patients with HIV-associated TBM. This work seeks to fill a gap in knowledge, as most previous studies have focused on individuals without HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with HIV who are also suffering from tuberculous meningitis.
Not a fit: Patients who do not have HIV or tuberculous meningitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of stroke risk in patients with HIV-associated TBM, potentially reducing morbidity and mortality.
How similar studies have performed: While there has been significant research on TBM and stroke in HIV-uninfected individuals, this specific focus on HIV-associated TBM is relatively novel and untested.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Abassi, Mahsa — University of Minnesota
- Study coordinator: Abassi, Mahsa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.