NIH-funded research R21 grant

Understanding brain blood flow changes in HIV-related TB meningitis and stroke.

Official title: Cerebral Hemodynamics and Stroke in HIV-associated TB Meningitis.

Funded at University of Minnesota · NIH-10892287 · Data updated 2026-11-12

This study is looking at how tuberculous meningitis affects blood flow in the brain and the risk of stroke for people living with HIV, using special imaging techniques to better understand these changes and their impact on long-term brain health.

More Hemodynamics research and trials

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniversity of Minnesota
NIH-funded
Lab location1 site (Minneapolis, United States)
Project startAugust 1, 2023
Project endJuly 31, 2025
Funding year2024
Award (this year)$125,253
NIH project number5R21NS134516-02
Project IDNIH-10892287 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals diagnosed with HIV who are also suffering from tuberculous meningitis.

Less likely to help

Patients who do not have HIV or tuberculous meningitis may not benefit from this research.

What this research studies

This research investigates how tuberculous meningitis (TBM) affects brain blood flow and the risk of stroke in individuals living with HIV. By using advanced imaging techniques like transcranial Doppler and brain scans, the study aims to identify changes in cerebral blood vessels and blood flow patterns. The researchers will explore how these changes relate to the risk of stroke and long-term neurological outcomes in patients with HIV-associated TBM. This work seeks to fill a gap in knowledge, as most previous studies have focused on individuals without HIV.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and management of stroke risk in patients with HIV-associated TBM, potentially reducing morbidity and mortality.

How similar studies have gone: While there has been significant research on TBM and stroke in HIV-uninfected individuals, this specific focus on HIV-associated TBM is relatively novel and untested.

Where this research is happening

  • University of Minnesota
    Minneapolis, United States
    Active

Researchers

  • Principal investigator: Abassi, Mahsa — University of Minnesota
  • Study coordinator: Abassi, Mahsa

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.