Tracking acute treatment and long-term outcomes in children with meningitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, multicenter clinical registry enrolling children under 18 with suspected acute infectious meningitis at roughly 20 public and private hospitals in Brazil. Clinical and laboratory data are recorded during hospitalization and follow-up visits occur at 28, 90, and 180 days after inclusion. Collected variables include timing and type of antibiotics, corticosteroid initiation, vaccination status, neurological sequelae, and access to rehabilitation services. Primary outcomes are all-cause mortality, hospital length of stay, rehospitalization rate, and incidence of sensorineural hearing loss, with additional etiology-specific and functional outcomes captured as secondary endpoints.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Fever (axillary temperature ≥37.8°C) followed by two or more of the following symptoms\*: severe headache, vomiting, altered consciousness (confusion, drowsiness, or irritability), photophobia (increased sensitivity to light), presence of seizures OR
* Fever accompanied by at least one meningeal irritation sign, such as neck stiffness, Kernig's sign, or Brudzinski's sign OR
* Sudden onset of fever and appearance of petechial skin rash or hemorrhagic suffusions

  * In children younger than two years, in addition to the presentations listed above, consider fever with any of the following: irritability, persistent crying, somnolence, or bulging fontanelle.

Exclusion Criteria:

* Refusal to provide consent for study participation

Where it's running

• Hospital Israelita Albert Einstein
  São Paulo, São Paulo, Brazil Recruiting

Study contacts

• Principal investigator: Anna M Gomes — Hospital Israelita Albert Einstein
• Study coordinator: Anna M Gomes
• Email: anna.gomes@einstein.br
• Phone: +55 11 2151-1233

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.