Improving diagnosis and treatment for meningitis in HIV/AIDS patients
Official title: Midcareer Mentoring for Clinical Research in HIV/AIDS-related cryptococcal and TB meningitis
Funded at University of Minnesota · NIH-10924701 · Data updated 2026-11-12
This study is all about finding better ways to diagnose and treat serious brain infections like cryptococcal and TB meningitis that can affect people with weakened immune systems, especially those living with HIV/AIDS, so we can help improve their health and care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 20, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $215,860 |
| NIH project number | 1K24AI184270-01 |
| Project ID | NIH-10924701 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who are living with HIV/AIDS and are at risk for cryptococcal or TB meningitis.
✕Less likely to help
Patients who do not have HIV/AIDS or are not at risk for central nervous system infections may not benefit from this research.
What this research studies
This research focuses on enhancing the understanding and management of central nervous system infections, particularly cryptococcal and TB meningitis, which significantly affect individuals with weakened immune systems, such as those living with HIV/AIDS. The project aims to develop better diagnostic tools, treatment protocols, and supportive care strategies through clinical trials and mentoring of new researchers in the field. By addressing these neglected diseases, the research seeks to influence international medical guidelines and improve patient outcomes across various income settings.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis, treatment, and prevention strategies for meningitis in patients with HIV/AIDS, potentially reducing mortality and disability rates.
How similar studies have gone: Previous research has shown success in improving outcomes for patients with similar conditions through enhanced diagnostic and treatment strategies, indicating a promising potential for this approach.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Boulware, David R — University of Minnesota
- Study coordinator: Boulware, David R
Related research
Other NIH-funded projects on the same topics.
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Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis
A study in Uganda aims to use faster, better tests and a new antifungal to help people with HIV who develop meningitis.
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Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-Related Meningitis
This project tests faster, better ways to diagnose HIV-related meningitis and improve brain health in adults in Africa.
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Better diagnosis and brain health for people with HIV meningitis
This project tries faster tests and a new oral antifungal to help adults with HIV who develop meningitis.
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Faster diagnosis and better brain health after HIV-associated meningitis
This project tests faster bedside and lab tests plus a new oral antifungal to help adults with HIV who develop meningitis.
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An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya
A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.
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FIOCRUZ HIV/AIDS Clinical Trials Unit: advancing HIV prevention and treatment in Brazil
A Brazilian clinical trials unit led by Dr. Beatriz Grinsztejn is testing and speeding up new HIV prevention and treatment strategies to help people living with HIV/AIDS and those at risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.