Comparing two antibiotics for treating Lyme meningitis in children
Official title: Comparative effectiveness and complications of intravenous ceftriaxone compared with oral doxycycline in Lyme meningitis
Funded at Boston Children's Hospital · NIH-10911066 · Data updated 2026-11-12
This study is looking at how well two different antibiotics work for treating Lyme meningitis in kids, to see which one helps them recover better and feel good in the long run, and it involves children from 20 places in the U.S. where Lyme disease is common.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $162,139 |
| NIH project number | 5R01AI151180-05 |
| Project ID | NIH-10911066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with Lyme meningitis.
✕Less likely to help
Patients with Lyme disease who do not have meningitis may not benefit from this research.
What this research studies
This research investigates the effectiveness and complications of two different antibiotics, intravenous ceftriaxone and oral doxycycline, for treating Lyme meningitis in children. The study aims to determine which treatment leads to better short-term recovery and long-term quality of life. It will involve enrolling children from 20 U.S. centers in areas where Lyme disease is common, and treatment decisions will be made by their doctors. Additionally, the research will gather insights from patients, parents, and clinicians to support shared decision-making regarding treatment options.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatment options for children with Lyme meningitis.
How similar studies have gone: Previous studies in adults have shown promising results with oral doxycycline, suggesting potential for success in this pediatric population.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Nigrovic, Lise E. — Boston Children's Hospital
- Study coordinator: Nigrovic, Lise E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.