Home › Trials › NCT05496673
Clinical trial Recruiting at 1 site Interventional

Investigating meningitis causes and prevention in rural Uganda

Official title: Meningitis: Burden, Causes, Screening and Prevention in Rural Northern Uganda

Run by University of Rochester · NCT05496673 · Data updated 2026-11-12

This study is trying to understand the causes and prevention of meningitis in rural Uganda by looking at patients with symptoms and screening HIV-positive individuals to improve care and vaccination efforts.

Quick facts

Study typeInterventional
SexAll
Enrollment11100 (estimated)
SponsorUniversity of Rochester
Academic / other
Locations1 site (Lira)
StatusRecruiting
StartedSeptember 1, 2022
Main results expectedSeptember 1, 2031
Study endsSeptember 1, 2031
Registry record updatedAugust 21, 2026
Trial IDNCT05496673 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients of all ages presenting with meningitis symptoms or HIV-infected individuals seeking care at the participating hospitals.

Probably not a fit

Patients who do not exhibit signs of meningitis or have alternative diagnoses explaining their symptoms will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the burden, causes, diagnostics, treatments, and preventive measures related to meningitis in northern Uganda. It will collect data from 1100 patients presenting with meningitis symptoms at Lira Regional Referral Hospital to assess the disease's impact and identify gaps in care. Additionally, the study will screen 10,000 HIV-infected patients for cryptococcal antigen to improve prevention strategies. The findings are expected to support advocacy for routine vaccination and enhanced screening guidelines.

Why it matters

Potential benefit: If successful, this study could lead to improved meningitis prevention and treatment strategies, ultimately saving lives in Uganda.

How similar studies have gone: While similar studies have been conducted, this specific approach focusing on rural Uganda's unique challenges presents a novel opportunity for impactful findings.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* 1100 patients who present with meningitis or meningitis symptoms, regardless of age or vulnerably status are eligible for meningitis testing.
* 10,000 HIV-infected patients presenting to LRRH, LRRH HIV Clinic (LIDC) or nearby outpatient clinics, regardless of age or vulnerability status, are eligible for CrAg screening.

Exclusion Criteria:

* Patients who are found not to have meningitis after initial evaluation, or are found to have other alternative diagnoses that explain their symptoms, will be excluded.
* HIV-negative patients without signs or symptoms of meningitis.

Where it's running

  • Lira Regional Referral Hospital
    Lira, Uganda     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
Browse more
Meningitis 56University of Rochester 896
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.