Community spread of multiple infectious diseases in Cambodia from a One Health perspective
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
This project will test how common and connected dengue, chikungunya, Zika, Japanese encephalitis, and West Nile infections are among people, animals, and the environment across Cambodia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 2 Years to 75 Years |
| Sex | All |
| Sponsor | Institut Pasteur du Cambodge Academic / other |
| Locations | 1 site (Phnom Penh, Phnom Penh) |
| Trial ID | NCT07358910 on ClinicalTrials.gov |
What this trial studies
RACSMEI is a nationwide One Health, multi-pathogen effort using a nationally representative population survey combined with animal and environmental sampling. The project pairs social-science interviews with multiplex laboratory diagnostics to test for 57 priority pathogens and builds a structured biobank and curated datasets. Mathematical modeling and integrated analysis will link burden, ecology, transmission patterns, and population immunity to inform public-health decisions. The program also includes capacity building and stakeholder engagement to strengthen national institutions and promote uptake of results.
Who should consider this trial
Good fit: Ideal participants are residents of selected Cambodian villages who have lived there more than six months, are between 2 and 75 years old, and can provide appropriate consent or parental consent and assent for minors.
Not a fit: People who live outside the selected Cambodian communities, are younger than 2 or older than 75, are under guardianship or deprived of liberty, unable to consent, or seeking direct medical treatment rather than survey participation are unlikely to benefit from this observational project.
Why it matters
Potential benefit: If successful, the project could enable targeted, culturally appropriate prevention and control measures and strengthen national surveillance to reduce infectious-disease burden.
How similar studies have performed: Similar multi-pathogen serosurveys and One Health approaches have produced useful public-health insights elsewhere, but a nationwide integrated effort covering 57 pathogens in Cambodia is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Residency in the village for more than 6 months; * Age between 2 and 75 years old at the time of inclusion; * For adults: provision of written consent; * For children aged 2-17 years: written parental consent form, verbal assent from children aged 13-17 years; Exclusion Criteria: * Unable to understand or consent; * Under guardianship or deprived of liberty; * Medical conditions that impede survey participation; * Refusal to participate in the study.
Where this trial is running
Phnom Penh, Phnom Penh
- Institut Pasteur du Cambodge — Phnom Penh, Phnom Penh, Cambodia (Recruiting)
Study contacts
- Principal investigator: Claude Flamand, Ph.D. — Institut Pasteur du Cambodge
- Study coordinator: Claude Flamand, Ph.D.
- Email: cflamand@pasteur-kh.org
- Phone: +855012333650
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.