Understanding long-term brain effects after cryptococcal meningitis in HIV patients
Late Neurological Sequelae after Cryptococcal Meningitis
['FUNDING_R21'] · INFECTIOUS DISEASES INSTITUTE · NIH-10999483
This study is looking at how cryptococcal meningitis affects the brain over time in people with HIV, to see if they have lasting memory or thinking problems and what might cause them, so we can find better ways to help improve their brain health.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INFECTIOUS DISEASES INSTITUTE (nih funded) |
| Locations | 1 site (KAMPALA, UGANDA) |
| Trial ID | NIH-10999483 on ClinicalTrials.gov |
What this research studies
This research investigates the long-term neurological effects experienced by survivors of cryptococcal meningitis, particularly in individuals living with HIV. It aims to assess the prevalence of sustained neurocognitive impairments and identify risk factors associated with these deficits. By utilizing quantitative neurocognitive performance assessments, the study seeks to understand how persistent cryptococcal antigens may contribute to chronic inflammation in the central nervous system. The findings will help inform future clinical trials focused on improving patient outcomes and reducing cognitive impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have survived cryptococcal meningitis and are living with HIV.
Not a fit: Patients who have not experienced cryptococcal meningitis or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing and mitigating long-term neurological complications in HIV patients who have survived cryptococcal meningitis.
How similar studies have performed: While there has been research on cryptococcal meningitis, this specific focus on long-term neurological sequelae and persistent antigenemia is relatively novel.
Where this research is happening
KAMPALA, UGANDA
- INFECTIOUS DISEASES INSTITUTE — KAMPALA, UGANDA (ACTIVE)
Researchers
- Principal investigator: NSANGI, LAURA JOAN — INFECTIOUS DISEASES INSTITUTE
- Study coordinator: NSANGI, LAURA JOAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus