How a fungal pathogen affects immune cell behavior
Manipulation of macrophage polarization by a fungal meningitis pathogen
This study is looking at how a fungus called Cryptococcus neoformans tricks our immune cells to help it survive and cause meningitis, with the goal of finding new ways to treat infections for people who are affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11086631 on NIH RePORTER |
What this research studies
This research investigates how the fungal pathogen Cryptococcus neoformans manipulates immune cells, particularly macrophages, to enhance its survival and cause meningitis. The study focuses on understanding the mechanisms by which this pathogen induces a type 2 immune response, which can make infections more severe. By examining the interactions between the fungus and various immune cells in the lungs, researchers aim to identify specific proteins that could be targeted for therapeutic interventions. The approach includes both in vitro experiments with immune cells and in vivo studies in animal models to assess the immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with fungal meningitis, particularly those with compromised immune systems.
Not a fit: Patients with non-fungal infections or those without immune system involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response against fungal infections, potentially improving outcomes for patients with fungal meningitis.
How similar studies have performed: Previous research has shown success in manipulating immune responses to combat infections, suggesting that this approach may yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Madhani, Hiten D — University of California, San Francisco
- Study coordinator: Madhani, Hiten D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.