Serological clues to survival in HIV-related cryptococcal meningitis

Who could benefit from this research

What this research studies

If you have HIV and develop cryptococcal meningitis, doctors want better ways to know who is at higher risk of dying and how to tailor treatment. The project will measure specific blood proteins called immunoglobulins to see if they relate to survival and response to therapy. By linking immune markers with outcomes, researchers hope to guide treatment choices and identify patients who may need intensified or different care. The work builds on past trials of antifungal regimens and aims to translate immune insights into practical, patient-centered decisions.

Why it matters

Where this research is happening

• Albert Einstein College of Medicine
  Bronx, United States Active

Researchers

• Principal investigator: Pirofski, Liise-Anne — Albert Einstein College of Medicine
• Study coordinator: Pirofski, Liise-Anne

Related research

Other NIH-funded projects on the same topics.

• Personalized Immunomodulatory Therapy for HIV-related Cryptococcal Meningitis

  A patient-focused study investigates a personalized treatment approach to improve outcomes for people with HIV who develop cryptococcal meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11615077

• Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis

  A study in Uganda aims to use faster, better tests and a new antifungal to help people with HIV who develop meningitis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11539368

• TB meningitis diagnostic test compare and cost study in sub-Saharan Africa

  Researchers are testing a new CSF urine-based test (SILVAMP TB LAM) to improve diagnosis of TB meningitis in people with HIV, to help speed treatment and reduce death in Sub-Saharan Africa.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11536232

• Minimally Invasive Sampling to Improve HIV-Associated M meningitis Diagnosis in Africa

  A research study is testing easier, less invasive ways to diagnose meningitis in people living with HIV, with a focus on making diagnosis faster and more accurate in Africa and the US.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11516017

• Understanding brain injury in kids with tuberculous meningitis (iThemba)

  A study in children with TB meningitis in South Africa will look at how inflammation and blood-clotting factors relate to brain injury and infarcts.

  NIH research Stellenbosch University · Stellenbosch, SOUTH AFRICA · NIH-11474075

• Blood-brain barrier problems during bacterial meningitis

  Researchers are studying why the brain’s protective barrier fails during bacterial meningitis and how that leads to brain injury, with a focus on how bacteria invade brain cells and disrupt protective transporters.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11431371

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.