Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-Related Meningitis
Funded at University of Minnesota · NIH-11406140 · Data updated 2026-11-12
This project tests faster, better ways to diagnose HIV-related meningitis and improve brain health in adults in Africa.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 1, 2013 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $297,733 |
| NIH project number | 5R01NS086312-13 |
| Project ID | NIH-11406140 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with HIV presenting with CNS infections in Uganda who have access to ART.
✕Less likely to help
Individuals without HIV, without CNS infections, or not in Uganda may not directly benefit.
What this research studies
If you have HIV and develop meningitis, quick and accurate tests can change outcomes. The study will enroll over 1,000 adults with CNS infections and HIV in Uganda to use rapid point-of-care and molecular diagnostics to identify the cause of meningitis. It also tests a new oral antifungal, oteseconazole, in a small clinical trial to see if it helps clear infection. The research aims to validate new tests like the CrAg-SQ lateral flow assay and an Xpert-HR Host Response gene signature for TB, potentially speeding treatment decisions. Results could lead to better survival and fewer long-term brain complications for people living with HIV and CNS infections.
Why it matters
Potential benefit: If successful, the findings could lead to faster, more accurate diagnoses and improved treatment options for HIV-related meningitis, reducing mortality and neurocognitive problems.
How similar studies have gone: Previous CNS infection studies in Africa have shown that rapid diagnostics can improve outcomes, but this project combines diagnostics with a proof-of-concept antifungal trial.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Boulware, David R — University of Minnesota
- Study coordinator: Boulware, David R
Related research
Other NIH-funded projects on the same topics.
-
Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related Meningitis
A study in Uganda aims to use faster, better tests and a new antifungal to help people with HIV who develop meningitis.
-
Better diagnosis and brain health for people with HIV meningitis
This project tries faster tests and a new oral antifungal to help adults with HIV who develop meningitis.
-
Faster diagnosis and better brain health after HIV-associated meningitis
This project tests faster bedside and lab tests plus a new oral antifungal to help adults with HIV who develop meningitis.
-
Improving diagnosis and treatment for meningitis in HIV/AIDS patients
This study is all about finding better ways to diagnose and treat serious brain infections like cryptococcal and TB meningitis that can affect people with weakened immune systems, especially those living with HIV/AIDS, so we can help improve their health and care.
-
An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya
A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.
-
FIOCRUZ HIV/AIDS Clinical Trials Unit: advancing HIV prevention and treatment in Brazil
A Brazilian clinical trials unit led by Dr. Beatriz Grinsztejn is testing and speeding up new HIV prevention and treatment strategies to help people living with HIV/AIDS and those at risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.